{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bastian K"],"funding":["Programme Hospitalier de la Recherche Clinique","Société Française d'Anesthésie - Réanimation"],"pagination":["2025-2037"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7095041"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(12)"],"pubmed_abstract":["PURPOSE:Intensive care unit survivors suffer from prolonged impairment, reduced quality of life, and higher mortality rates after discharge compared to the general population. Socioeconomic status may play a partial but important role in mortality and recovery. Therefore, the detection of factors that are responsible for poor long-term outcomes would be beneficial in designing targeted interventions for at-risk populations. METHODS:For an endpoint analysis, 1834 intensive care unit patients with known French Deprivation Index (FDep) scores were included from the French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) study, which was a prospective, observational, multicenter cohort study performed in 20 French intensive care units in 13 different hospitals. Socioeconomic status was defined by using the FDep score [represented as quintiles when referring to the general French population, as quintiles when referring to the FROG-ICU cohort, or as dichotomized data (which was defined as a FDep???0 for nondeprived patients)] and by using a detailed social questionnaire that was completed 3 months after discharge. The primary outcome included an all-cause, 1-year mortality after ICU discharge when regarding socioeconomic status. The secondary outcomes included both ICU and hospital lengths of stay, both short- and medium-term mortality, and the quality of life, as assessed during the 1-year follow-up by using the Medical Outcome Survey Short Form-36 (SF-36). The Revised Impact of Event Scale (IES-R) was used to evaluate the symptoms of post-traumatic stress disorder, and the Hospital Anxiety and Depression Scale (HADS) was used to screen for anxiety and depression. RESULTS:Of the 1447 patients who were discharged alive from the ICU, 19.2% died over the following year. No association was found between 1-year mortality and socioeconomic status, regardless of whether this association was analyzed in quintiles (p?=?0.911 in the quintiles of the general French population; p?=?0.589 in the quintiles of the FROG-ICU cohort itself) or as dichotomized data [nondeprived (n?=?177; 1-year mortality of 18.2%) versus deprived (n?=?97; 1-year mortality of 20.5%; p?=?0.304)]. Moreover, no differences were found between the nondeprived and the deprived patients in the ICU and hospital lengths of stay, ICU mortalities, in-hospital mortalities, or 28-day mortalities. The SF-36 was below the score for the normal French population throughout the follow-up period. Socially deprived patients showed significantly lower median scores in the physical function subscale [55, interquartile range (IQR) (28.8-80) vs. 65, IQR (35-90); p?=?0.014], the physical role subscale [25, IQR (0-75) vs. 33.3, IQR (0-100); p?=?0.022], and the overall physical component scale [47.5, IQR (30-68.8) vs. 54.4, IQR (35-78.8); p?=?0.010]. Up to 31.6% of survivors presented symptoms that indicated post-traumatic stress disorder, and up to 31.5% of survivors reported clinically meaningful symptoms of anxiety or depression. CONCLUSIONS:A lower socioeconomic status was associated with lower self-reported physical component scores in the nondeprived patients. Psychiatric symptoms are frequently reported after an ICU stay, and subsequent interventions should target those fields. TRIAL REGISTRATION:ClinicalTrials.gov NCT01367093; registered on June 6, 2011."],"journal":["Intensive care medicine"],"pubmed_title":["Association of social deprivation with 1-year outcome of ICU survivors: results from the FROG-ICU study."],"pmcid":["PMC7095041"],"funding_grant_id":["N/A","AON 10-216"],"pubmed_authors":["Azoulay E","Siegemund M","Gayat E","Chevreul K","Fournier MC","Sonneville R","FROG-ICU Study Investigators","Feliot E","Pili-Floury S","Bastian K","Hollinger A","Guidet B","Michel M","Montravers P","Mebazaa A"],"additional_accession":[]},"is_claimable":false,"name":"Association of social deprivation with 1-year outcome of ICU survivors: results from the FROG-ICU study.","description":"PURPOSE:Intensive care unit survivors suffer from prolonged impairment, reduced quality of life, and higher mortality rates after discharge compared to the general population. Socioeconomic status may play a partial but important role in mortality and recovery. Therefore, the detection of factors that are responsible for poor long-term outcomes would be beneficial in designing targeted interventions for at-risk populations. METHODS:For an endpoint analysis, 1834 intensive care unit patients with known French Deprivation Index (FDep) scores were included from the French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) study, which was a prospective, observational, multicenter cohort study performed in 20 French intensive care units in 13 different hospitals. Socioeconomic status was defined by using the FDep score [represented as quintiles when referring to the general French population, as quintiles when referring to the FROG-ICU cohort, or as dichotomized data (which was defined as a FDep???0 for nondeprived patients)] and by using a detailed social questionnaire that was completed 3 months after discharge. The primary outcome included an all-cause, 1-year mortality after ICU discharge when regarding socioeconomic status. The secondary outcomes included both ICU and hospital lengths of stay, both short- and medium-term mortality, and the quality of life, as assessed during the 1-year follow-up by using the Medical Outcome Survey Short Form-36 (SF-36). The Revised Impact of Event Scale (IES-R) was used to evaluate the symptoms of post-traumatic stress disorder, and the Hospital Anxiety and Depression Scale (HADS) was used to screen for anxiety and depression. RESULTS:Of the 1447 patients who were discharged alive from the ICU, 19.2% died over the following year. No association was found between 1-year mortality and socioeconomic status, regardless of whether this association was analyzed in quintiles (p?=?0.911 in the quintiles of the general French population; p?=?0.589 in the quintiles of the FROG-ICU cohort itself) or as dichotomized data [nondeprived (n?=?177; 1-year mortality of 18.2%) versus deprived (n?=?97; 1-year mortality of 20.5%; p?=?0.304)]. Moreover, no differences were found between the nondeprived and the deprived patients in the ICU and hospital lengths of stay, ICU mortalities, in-hospital mortalities, or 28-day mortalities. The SF-36 was below the score for the normal French population throughout the follow-up period. Socially deprived patients showed significantly lower median scores in the physical function subscale [55, interquartile range (IQR) (28.8-80) vs. 65, IQR (35-90); p?=?0.014], the physical role subscale [25, IQR (0-75) vs. 33.3, IQR (0-100); p?=?0.022], and the overall physical component scale [47.5, IQR (30-68.8) vs. 54.4, IQR (35-78.8); p?=?0.010]. Up to 31.6% of survivors presented symptoms that indicated post-traumatic stress disorder, and up to 31.5% of survivors reported clinically meaningful symptoms of anxiety or depression. CONCLUSIONS:A lower socioeconomic status was associated with lower self-reported physical component scores in the nondeprived patients. Psychiatric symptoms are frequently reported after an ICU stay, and subsequent interventions should target those fields. TRIAL REGISTRATION:ClinicalTrials.gov NCT01367093; registered on June 6, 2011.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2020-11-08T09:10:02Z","creation":"2020-05-22T14:32:00Z"},"accession":"S-EPMC7095041","cross_references":{"pubmed":["30353380"],"doi":["10.1007/s00134-018-5412-5"]}}