biostudies-literatureDewan MNICHD NIH HHS218-225https://www.ebi.ac.uk/biostudies/studies/S-EPMC7096320biostudies-literatureUnknown11(2)<h4>Background</h4>Sepsis is an uncontrolled inflammatory reaction caused by infection. Clinicians in the pediatric intensive care unit (PICU) developed a paper-based tool to identify patients at risk of sepsis. To improve the utilization of the tool, the PICU team integrated the paper-based tool as a real-time clinical decision support (CDS) intervention in the electronic health record (EHR).<h4>Objective</h4>This study aimed to improve identification of PICU patients with sepsis through an automated EHR-based CDS intervention.<h4>Methods</h4>A prospective cohort study of all patients admitted to the PICU from May 2017 to May 2019. A CDS intervention was implemented in May 2018. The CDS intervention screened patients for nonspecific sepsis criteria, temperature dysregulation and a blood cApplied clinical informaticsDesign, Implementation, and Validation of a Pediatric ICU Sepsis Prediction Tool as Clinical Decision Support.PMC7096320L40 HD085270Zackoff MPaff ZHagedorn PVidrine RStalets ELDewan MSeger BPfeiffer SfalseDesign, Implementation, and Validation of a Pediatric ICU Sepsis Prediction Tool as Clinical Decision Support.<h4>Background</h4>Sepsis is an uncontrolled inflammatory reaction caused by infection. Clinicians in the pediatric intensive care unit (PICU) developed a paper-based tool to identify patients at risk of sepsis. To improve the utilization of the tool, the PICU team integrated the paper-based tool as a real-time clinical decision support (CDS) intervention in the electronic health record (EHR).<h4>Objective</h4>This study aimed to improve identification of PICU patients with sepsis through an automated EHR-based CDS intervention.<h4>Methods</h4>A prospective cohort study of all patients admitted to the PICU from May 2017 to May 2019. A CDS intervention was implemented in May 2018. The CDS intervention screened patients for nonspecific sepsis criteria, temperature dysregulation and a blood c2020-01-01T00:00:00Z2020 Mar2025-04-19T16:17:27.368Z2025-04-19T16:17:27.368ZS-EPMC70963203221589310.1055/s-0040-1705107