biostudies-literatureRincon-Fontan MXunta de GaliciaUniversidade de VigoEuropean CommissionMinisterio de Educaci?n, Cultura y Deporte5704-5712https://www.ebi.ac.uk/biostudies/studies/S-EPMC7097895biostudies-literatureUnknown5(11)The cosmetic industry provides a wide variety of shampoos to treat dandruff, containing insoluble ingredients such as Zn pyrithione. However, the solubility of this active ingredient is quite limited in both water and oil media; thus, antidandruff formulations must include a large amount of chemically synthesized stabilizing ingredients to avoid their precipitation. In this work, the stabilization of Zn pyrithione in O/W emulsions using a biosurfactant (BS) extract and Tween 80 is studied. The study includes an incomplete factorial design based on the tea tree oil/water ratio and both surfactant and biosurfactant concentrations. The formulations are characterized in terms of particle size, stability after 30 days, and solubility of Zn pyrithione. The formulation that provided the most favoACS omegaNovel Multifunctional Biosurfactant Obtained from Corn as a Stabilizing Agent for Antidandruff Formulations Based on Zn Pyrithione Powder.PMC7097895FPU15/00205IJCI-2016-27445ED431B 2017/77Rincon-Fontan MRodriguez-Lopez LMoldes ABVecino XCruz JMfalseNovel Multifunctional Biosurfactant Obtained from Corn as a Stabilizing Agent for Antidandruff Formulations Based on Zn Pyrithione Powder.The cosmetic industry provides a wide variety of shampoos to treat dandruff, containing insoluble ingredients such as Zn pyrithione. However, the solubility of this active ingredient is quite limited in both water and oil media; thus, antidandruff formulations must include a large amount of chemically synthesized stabilizing ingredients to avoid their precipitation. In this work, the stabilization of Zn pyrithione in O/W emulsions using a biosurfactant (BS) extract and Tween 80 is studied. The study includes an incomplete factorial design based on the tea tree oil/water ratio and both surfactant and biosurfactant concentrations. The formulations are characterized in terms of particle size, stability after 30 days, and solubility of Zn pyrithione. The formulation that provided the most favo2020-01-01T00:00:00Z2020 Mar2026-05-07T11:23:59.081Z2020-05-22T15:36:00ZS-EPMC70978953222684810.1021/acsomega.9b03679