biostudies-literatureUnknown5(11)Omer WEInstitute of Nanotechnology, Kafrelsheikh UniversityDr. Mohamed S. Attia Lab, Ain Shams UniversityWe developed a novel, simple, sensitive, accurate, and precise method for the determination of calcitonin in different serum samples with medullar thyroid carcinoma. The designed flower-like thin film gold nanoparticles doped in a sol-gel/polyethylene glycol mold are used as an optical biosensor for the efficient determination of calcitonin. The sensor was characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray microanalysis, and Fourier-transform infrared spectroscopy. The efficiency of the considered bio-sensor is done using the quencher calcitonin of the emission band at 360 nm of biomarker obtained at λ_ex = 333 nm in acetonitrile solvent. The sensing mechanism was based on fluorescence resonance energy transACS omega5629-5637https://www.ebi.ac.uk/biostudies/studies/S-EPMC7097903biostudies-literatureHighly Efficient Gold Nano-Flower Optical Biosensor Doped in a Sol-Gel/PEG Matrix for the Determination of a Calcitonin Biomarker in Different Serum Samples.PMC7097903Omer WEElsaady MMYoussef AOAttia MSEl-Kemary MAGouda AAAbou-Omar MNSayqal AAfalseHighly Efficient Gold Nano-Flower Optical Biosensor Doped in a Sol-Gel/PEG Matrix for the Determination of a Calcitonin Biomarker in Different Serum Samples.We developed a novel, simple, sensitive, accurate, and precise method for the determination of calcitonin in different serum samples with medullar thyroid carcinoma. The designed flower-like thin film gold nanoparticles doped in a sol-gel/polyethylene glycol mold are used as an optical biosensor for the efficient determination of calcitonin. The sensor was characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray microanalysis, and Fourier-transform infrared spectroscopy. The efficiency of the considered bio-sensor is done using the quencher calcitonin of the emission band at 360 nm of biomarker obtained at λ_ex = 333 nm in acetonitrile solvent. The sensing mechanism was based on fluorescence resonance energy trans2020-01-01T00:00:00Z2020 Mar2025-04-20T01:39:51.305Z2020-05-22T15:36:06ZS-EPMC70979033222683810.1021/acsomega.9b02833