{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Oliai Araghi S"],"funding":["Ministerie van Economische Zaken","Nederlandse Zuivel Organisatie","ZonMw"],"pagination":["1253-1262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7098930"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59(3)"],"pubmed_abstract":["Purpose
Higher folate and vitamin-B12 have been linked to lower risk of overweight. However, whether this is a causal effect of these B-vitamins on obesity risk remains unclear and evidence in older individuals is scarce. This study aimed to assess the role of B-vitamin supplementation and levels on body composition in older individuals.Methods
A double-blind, randomized controlled trial in 2919 participants aged ≥ 65 years with elevated homocysteine levels. The intervention comprised a 2-year supplementation with a combination of folic acid (400 µg) and vitamin B12 (500 µg), or with placebo. Serum folate, vitamin-B12, active vitamin-B12 (HoloTC), methylmalonic acid (MMA), and anthropometrics were measured at baseline and after 2 years of follow-up. Dietary intake of folate"],"journal":["European journal of nutrition"],"pubmed_title":["B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study."],"pmcid":["PMC7098930"],"funding_grant_id":["6130.0031","project KB-15-004-003"],"pubmed_authors":["Kiefte-de Jong JC","Zillikens MC","Uitterlinden AG","van Schoor NM","Voortman T","Oliai Araghi S","van Dijk SC","Stricker BH","van der Velde N","Braun KVE","de Groot LCPGM"],"additional_accession":[]},"is_claimable":false,"name":"B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study.","description":"Purpose
Higher folate and vitamin-B12 have been linked to lower risk of overweight. However, whether this is a causal effect of these B-vitamins on obesity risk remains unclear and evidence in older individuals is scarce. This study aimed to assess the role of B-vitamin supplementation and levels on body composition in older individuals.Methods
A double-blind, randomized controlled trial in 2919 participants aged ≥ 65 years with elevated homocysteine levels. The intervention comprised a 2-year supplementation with a combination of folic acid (400 µg) and vitamin B12 (500 µg), or with placebo. Serum folate, vitamin-B12, active vitamin-B12 (HoloTC), methylmalonic acid (MMA), and anthropometrics were measured at baseline and after 2 years of follow-up. Dietary intake of folate","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2026-04-28T23:05:17.961Z","creation":"2020-05-22T14:43:14Z"},"accession":"S-EPMC7098930","cross_references":{"pubmed":["31076856"],"doi":["10.1007/s00394-019-01985-8"]}}