biostudies-literatureSun XHospital-level Fund of Yueyang Integrated traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of traditional Chinese MedicineNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaShanghai Development Office of TCM299https://www.ebi.ac.uk/biostudies/studies/S-EPMC7106809biostudies-literatureUnknown21(1)<h4>Background</h4>Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and advantages. Although a combination of TCM and WM therapies, adjusted to the clinical situation, is widely used, there are no systematic studies on the hierarchical selection of this treatment combination based on the severity of skin lesions. We therefore designed a randomized clinical trial to focus on the sequence of internal and external treatments of TCM in patients with mild-to-moderate plaque psoriasis and to optimize the integration of Chinese and western medicine for the treatment of patients with severe plaque psoriasis, thereby achieving high-level clinicTrialsOur Choice: study protocol for a randomized controlled trial for optimal implementation of psoriasis treatment by the integration of Chinese and western medicine.PMC7106809819738602019YYQ3181874470ZY [2018-2020]-FWTX-10082018YFC1705304ZY(2018-2020)-CCCX-2004-08Liu LHuang NGuo SSun XZhou XWei YYang CYang WLi XDing XDing YWang RZhang YWeng HYin QChen XLi BHu RfalseOur Choice: study protocol for a randomized controlled trial for optimal implementation of psoriasis treatment by the integration of Chinese and western medicine.<h4>Background</h4>Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and advantages. Although a combination of TCM and WM therapies, adjusted to the clinical situation, is widely used, there are no systematic studies on the hierarchical selection of this treatment combination based on the severity of skin lesions. We therefore designed a randomized clinical trial to focus on the sequence of internal and external treatments of TCM in patients with mild-to-moderate plaque psoriasis and to optimize the integration of Chinese and western medicine for the treatment of patients with severe plaque psoriasis, thereby achieving high-level clinic2020-01-01T00:00:00Z2020 Mar2026-05-03T18:55:16.466Z2020-05-22T15:37:15ZS-EPMC71068093222872010.1186/s13063-020-4209-3