{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mannhardt C"],"funding":["Bundesministerium für Bildung und Forschung"],"pagination":["e0230426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7108707"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(3)"],"pubmed_abstract":["<h4>Objective</h4>Postnatal vitamin D supplementation is standard of care in neonates and preterm infants. Despite routine supplementation of vitamin D, a wide range of complications related to vitamin D deficiency has been described in the literature. Since standard vitamin D supplementation might be not sufficient in preterm infants with a genetic predisposition for vitamin D deficiency, we investigated the outcome of preterm infants with regard to their genetic estimated vitamin D levels.<h4>Methods</h4>Preterm infants with a birth weight below 1500 grams were included in the German Neonatal Network at the time of their birth and tested at the age of five. The vitamin D level was genetically calculated based on three single nucleotide polymorphisms (SNPs: rs12794714, rs7944926 and rs2282679) which alter vitamin D synthesis pathways. Specific alleles of these polymorphisms are validated markers for low plasma vitamin D levels. Outcome data were based on baseline data at the time of birth, typical complications of prematurity, body measurements at the age of five and occurrence of bone fractures. T-test and Fisher's exact test were used for statistical comparison.<h4>Results</h4>According to their genetic predisposition, 1,924 preterm infants were divided into groups of low (gsVitD < 20. Percentile), intermediate and high vitamin D level estimates. Low genetic vitamin D level estimates could not be shown to be associated with any adverse outcome measures examined. The analyses covered data on aforementioned determinants.<h4>Conclusion</h4>Low genetic vitamin D level estimates could not be shown to be associated with previously described adverse outcome in preterm infants."],"journal":["PloS one"],"pubmed_title":["Genetic predisposition for vitamin D deficiency is not associated with adverse outcome of very low birth weight infants: A cohort study from the German Neonatal Network."],"pmcid":["PMC7108707"],"funding_grant_id":["BMBF 01ER0805 &amp; BMBF 01ER1501"],"pubmed_authors":["Spiegler J","Mannhardt C","Rausch TK","Humberg A","Gopel W","Swoboda I","Fortmann MI"],"additional_accession":[]},"is_claimable":false,"name":"Genetic predisposition for vitamin D deficiency is not associated with adverse outcome of very low birth weight infants: A cohort study from the German Neonatal Network.","description":"<h4>Objective</h4>Postnatal vitamin D supplementation is standard of care in neonates and preterm infants. Despite routine supplementation of vitamin D, a wide range of complications related to vitamin D deficiency has been described in the literature. Since standard vitamin D supplementation might be not sufficient in preterm infants with a genetic predisposition for vitamin D deficiency, we investigated the outcome of preterm infants with regard to their genetic estimated vitamin D levels.<h4>Methods</h4>Preterm infants with a birth weight below 1500 grams were included in the German Neonatal Network at the time of their birth and tested at the age of five. The vitamin D level was genetically calculated based on three single nucleotide polymorphisms (SNPs: rs12794714, rs7944926 and rs2282679) which alter vitamin D synthesis pathways. Specific alleles of these polymorphisms are validated markers for low plasma vitamin D levels. Outcome data were based on baseline data at the time of birth, typical complications of prematurity, body measurements at the age of five and occurrence of bone fractures. T-test and Fisher's exact test were used for statistical comparison.<h4>Results</h4>According to their genetic predisposition, 1,924 preterm infants were divided into groups of low (gsVitD < 20. Percentile), intermediate and high vitamin D level estimates. Low genetic vitamin D level estimates could not be shown to be associated with any adverse outcome measures examined. The analyses covered data on aforementioned determinants.<h4>Conclusion</h4>Low genetic vitamin D level estimates could not be shown to be associated with previously described adverse outcome in preterm infants.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-07T18:46:32.132Z","creation":"2026-04-07T16:46:51.929Z"},"accession":"S-EPMC7108707","cross_references":{"pubmed":["32231377"],"doi":["10.1371/journal.pone.0230426"]}}