{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dai Y"],"funding":["Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China","Ministry of Agriculture"],"pagination":["48-55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7111660"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55"],"pubmed_abstract":["L-type lectins are involved in glycoproteins secretory pathways and are associated with many immune responses. There is growing evidence that L-type lectins are also involved in viral replication. In this study, a novel L-type lectin (named as PcL-lectin) was identified from red swamp crayfish (Procambarus clakii). Gene sequencing and phylogenetic tree analysis results showed that the PcL-lectin was a kind of endoplasmic reticulum Golgi intermediate compartment-53 (ERGIC-53). The expression level of PcL-lectin was significantly down regulated in crayfish after challenged with white spot syndrome virus (WSSV). Recombinant PcL-lectin protein facilitated the replication of WSSV in crayfish. In addition, WSSV replication was decreased when endogenous PcL-lectin was knocked down by RNA interfer"],"journal":["Fish & shellfish immunology"],"pubmed_title":["A novel L-type lectin was required for the multiplication of WSSV in red swamp crayfish (Procambarus clakii)."],"pmcid":["PMC7111660"],"funding_grant_id":["31372563","31502199","2015QC019","31572657","2014PY035","201401"],"pubmed_authors":["Qin Q","Zhao L","Qin Z","Wang Y","Lin L","Dai Y","Yuan J","Lan J"],"additional_accession":[]},"is_claimable":false,"name":"A novel L-type lectin was required for the multiplication of WSSV in red swamp crayfish (Procambarus clakii).","description":"L-type lectins are involved in glycoproteins secretory pathways and are associated with many immune responses. There is growing evidence that L-type lectins are also involved in viral replication. In this study, a novel L-type lectin (named as PcL-lectin) was identified from red swamp crayfish (Procambarus clakii). Gene sequencing and phylogenetic tree analysis results showed that the PcL-lectin was a kind of endoplasmic reticulum Golgi intermediate compartment-53 (ERGIC-53). The expression level of PcL-lectin was significantly down regulated in crayfish after challenged with white spot syndrome virus (WSSV). Recombinant PcL-lectin protein facilitated the replication of WSSV in crayfish. In addition, WSSV replication was decreased when endogenous PcL-lectin was knocked down by RNA interfer","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2025-06-01T12:22:41.039Z","creation":"2025-06-01T12:22:41.039Z"},"accession":"S-EPMC7111660","cross_references":{"pubmed":["27208793"],"doi":["10.1016/j.fsi.2016.05.020"]}}