{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu L"],"funding":["“Blue Ocean Talent Plan” Innovation and Entrepreneurship Team","National Natural Science Foundation of China","Beijing Technology and Business University"],"pagination":["560-569"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7112149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(4)"],"pubmed_abstract":["This article focuses on the establishment of an accurate and sensitive quantitation method for the analysis of furan fatty acids. In particular, the sensitivity of GC/MS and UPLC/ESI/MS/MS was compared for the identification and quantification of furan fatty acids. Different methylation methods were tested with respect to GC/MS analysis. Special attention needs to be paid to the methylation of furan fatty acids, as acidic catalysts might lead to the degradation of the furan ring. GC/MS analysis in full-scan mode demonstrated that the limit of quantitation was 10 μM. UPLC/ESI/MS/MS in multiple reaction monitoring mode displayed a higher detection sensitivity than GC/MS. Moreover, the identification of furan fatty acids with charge-reversal derivatization was tested in the positive mode with"],"journal":["Journal of lipid research"],"pubmed_title":["Development of a sensitive and quantitative method for the identification of two major furan fatty acids in human plasma."],"pmcid":["PMC7112149"],"funding_grant_id":["201811070001","31601398","20171049"],"pubmed_authors":["Xu L","Liu Y","Yin H","Hu C","Li S","Wang Y","Vetter W"],"additional_accession":[]},"is_claimable":false,"name":"Development of a sensitive and quantitative method for the identification of two major furan fatty acids in human plasma.","description":"This article focuses on the establishment of an accurate and sensitive quantitation method for the analysis of furan fatty acids. In particular, the sensitivity of GC/MS and UPLC/ESI/MS/MS was compared for the identification and quantification of furan fatty acids. Different methylation methods were tested with respect to GC/MS analysis. Special attention needs to be paid to the methylation of furan fatty acids, as acidic catalysts might lead to the degradation of the furan ring. GC/MS analysis in full-scan mode demonstrated that the limit of quantitation was 10 μM. UPLC/ESI/MS/MS in multiple reaction monitoring mode displayed a higher detection sensitivity than GC/MS. Moreover, the identification of furan fatty acids with charge-reversal derivatization was tested in the positive mode with","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2026-05-07T10:54:21.248Z","creation":"2026-04-07T22:47:11.953Z"},"accession":"S-EPMC7112149","cross_references":{"pubmed":["32029512"],"doi":["10.1194/jlr.d119000514","10.1194/jlr.D119000514"]}}