{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hasan Z"],"funding":["United States National Institute of Occupational Safety and Health","United States National Institute of Environmental Health Sciences","ACL HHS","NIEHS NIH HHS","Innovative Talent Team Training Project of Zunyi City","NIOSH CDC HHS","National Natural Science Foundation of China","NCI NIH HHS","Natural Science Foundation of Guizhou Provincial Scientific and Technology Department","International Scientific and Technology cooperation project of Guizhou Province"],"pagination":["126469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7112220"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59"],"pubmed_abstract":["Objectives
Aluminum (Al) is a neurotoxicant; however, efforts to understand Al toxicity are limited by the lack of a quantitative biomarker of cumulative exposure. Bone Al measurements may address this need. Here, we describe and compare non-invasive bone Al measurements with fingernail Al and Al cumulative exposure indices (CEIs).Methods
We completed a cross-sectional study of 43 factory workers in Zunyi, China. Bone Al measurements were taken with a compact in-vivo neutron activation analysis system (IVNAA). Fingernail samples were analyzed using inductively coupled plasma mass spectrometry. CEIs, based on self-reported work history and prior literature, were calculated for the prior 5, 10, 15, 20 years and lifetime work history. Linear regressions adjusted for age and ed"],"journal":["Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)"],"pubmed_title":["Characterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China."],"pmcid":["PMC7112220"],"funding_grant_id":["2015-42","RO1ES027078","T03OH008615","R13 ES030964","R01 ES027078","T42 OH008455","G2014-7012","81760582","R21 OH010700","R21OH010700","T32 CA147832","T03 OH008615","2017-1215"],"pubmed_authors":["Rolle-McFarland D","Liu Y","Li Y","Nie LH","Hasan Z","Mostafaei F","Fan Q","Zhou Y","Zheng W","Wells EM","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China.","description":"Objectives
Aluminum (Al) is a neurotoxicant; however, efforts to understand Al toxicity are limited by the lack of a quantitative biomarker of cumulative exposure. Bone Al measurements may address this need. Here, we describe and compare non-invasive bone Al measurements with fingernail Al and Al cumulative exposure indices (CEIs).Methods
We completed a cross-sectional study of 43 factory workers in Zunyi, China. Bone Al measurements were taken with a compact in-vivo neutron activation analysis system (IVNAA). Fingernail samples were analyzed using inductively coupled plasma mass spectrometry. CEIs, based on self-reported work history and prior literature, were calculated for the prior 5, 10, 15, 20 years and lifetime work history. Linear regressions adjusted for age and ed","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-19T16:17:06.767Z","creation":"2022-02-09T18:08:15.349Z"},"accession":"S-EPMC7112220","cross_references":{"pubmed":["31982817"],"doi":["10.1016/j.jtemb.2020.126469"]}}