biostudies-literatureHasan ZUnited States National Institute of Occupational Safety and HealthUnited States National Institute of Environmental Health SciencesACL HHSNIEHS NIH HHSInnovative Talent Team Training Project of Zunyi CityNIOSH CDC HHSNational Natural Science Foundation of ChinaNCI NIH HHSNatural Science Foundation of Guizhou Provincial Scientific and Technology DepartmentInternational Scientific and Technology cooperation project of Guizhou Province126469https://www.ebi.ac.uk/biostudies/studies/S-EPMC7112220biostudies-literatureUnknown59<h4>Objectives</h4>Aluminum (Al) is a neurotoxicant; however, efforts to understand Al toxicity are limited by the lack of a quantitative biomarker of cumulative exposure. Bone Al measurements may address this need. Here, we describe and compare non-invasive bone Al measurements with fingernail Al and Al cumulative exposure indices (CEIs).<h4>Methods</h4>We completed a cross-sectional study of 43 factory workers in Zunyi, China. Bone Al measurements were taken with a compact in-vivo neutron activation analysis system (IVNAA). Fingernail samples were analyzed using inductively coupled plasma mass spectrometry. CEIs, based on self-reported work history and prior literature, were calculated for the prior 5, 10, 15, 20 years and lifetime work history. Linear regressions adjusted for age and edJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)Characterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China.PMC71122202015-42RO1ES027078T03OH008615R13 ES030964R01 ES027078T42 OH008455G2014-701281760582R21 OH010700R21OH010700T32 CA147832T03 OH0086152017-1215Rolle-McFarland DLiu YLi YNie LHHasan ZMostafaei FFan QZhou YZheng WWells EMZhou JfalseCharacterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China.<h4>Objectives</h4>Aluminum (Al) is a neurotoxicant; however, efforts to understand Al toxicity are limited by the lack of a quantitative biomarker of cumulative exposure. Bone Al measurements may address this need. Here, we describe and compare non-invasive bone Al measurements with fingernail Al and Al cumulative exposure indices (CEIs).<h4>Methods</h4>We completed a cross-sectional study of 43 factory workers in Zunyi, China. Bone Al measurements were taken with a compact in-vivo neutron activation analysis system (IVNAA). Fingernail samples were analyzed using inductively coupled plasma mass spectrometry. CEIs, based on self-reported work history and prior literature, were calculated for the prior 5, 10, 15, 20 years and lifetime work history. Linear regressions adjusted for age and ed2020-01-01T00:00:00Z2020 May2025-04-19T16:17:06.767Z2022-02-09T18:08:15.349ZS-EPMC71122203198281710.1016/j.jtemb.2020.126469