{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kluin-Nelemans HC"],"funding":["Austrian Science Fund FWF","Deutsche Forschungsgemeinschaft"],"pagination":["1090-1101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7115841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(4)"],"pubmed_abstract":["Systemic mastocytosis (SM) is frequently associated with eosinophilia. To examine its prevalence and clinical impact in all WHO classification-based subcategories, we analyzed eosinophil counts in 2350 mastocytosis patients using the dataset of the European Competence Network on Mastocytosis. Ninety percent of patients had normal eosinophil counts, 6.8% mild eosinophilia (0.5-1.5 × 10<sup>9</sup>/l), and 3.1% hypereosinophilia (HE; >1.5 × 10<sup>9</sup>/l). Eosinophilia/HE were mainly present in patients with advanced SM (17%/19%), and only rarely recorded in patients with indolent and smoldering SM (5%/1%), and some patients with cutaneous mastocytosis. The eosinophil count correlated with organomegaly, dysmyelopoiesis, and the WHO classification, but not with mediator-related symptoms or"],"journal":["Leukemia"],"pubmed_title":["Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry."],"pmcid":["PMC7115841"],"funding_grant_id":["F 4701","RA2838","F 4704"],"pubmed_authors":["Shoumariyeh K","Zanotti R","Breynaert C","Panse J","Niedoszytko M","Mattsson M","Elena C","Rossignol J","Jawhar M","Scaffidi L","Niederwieser D","Fortina AB","Jakob T","Perkins C","Doubek M","Lortholary O","Parente R","Valent P","Gorska A","Varkonyi J","Sabato V","Illerhaus A","Lange M","Kilbertus A","Arock M","Aberer E","Gotlib J","Hagglund H","Hermine O","Zink A","Hartmann K","von Bubnoff N","Bonadonna P","Triggiani M","Schwaab J","van Anrooij B","Caroppo F","Kennedy V","Yavuz AS","Reiter A","Brockow K","Fuchs D","Sperr WR","Span LFR","Malcovati L","Kluin-Nelemans HC"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry.","description":"Systemic mastocytosis (SM) is frequently associated with eosinophilia. To examine its prevalence and clinical impact in all WHO classification-based subcategories, we analyzed eosinophil counts in 2350 mastocytosis patients using the dataset of the European Competence Network on Mastocytosis. Ninety percent of patients had normal eosinophil counts, 6.8% mild eosinophilia (0.5-1.5 × 10<sup>9</sup>/l), and 3.1% hypereosinophilia (HE; >1.5 × 10<sup>9</sup>/l). Eosinophilia/HE were mainly present in patients with advanced SM (17%/19%), and only rarely recorded in patients with indolent and smoldering SM (5%/1%), and some patients with cutaneous mastocytosis. The eosinophil count correlated with organomegaly, dysmyelopoiesis, and the WHO classification, but not with mediator-related symptoms or","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-21T20:14:23.521Z","creation":"2020-09-17T07:08:11Z"},"accession":"S-EPMC7115841","cross_references":{"pubmed":["31740811"],"doi":["10.1038/s41375-019-0632-4"]}}