{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(8)"],"submitter":["Hulpia F"],"pubmed_abstract":["A series of new nucleoside analogues based on a C-3 branched ethynyl sugar derivative as present in 3'-C-ethynylcytidine (ECyd) and -adenosine (EAdo), combined with modified purine bases was synthetized and evaluated against a broad array of viruses and tumour cell lines. The pronounced cytostatic activity of EAdo was confirmed. EAdo and its 2,6-diaminopurine analogue showed inhibitory activity against vaccinia virus (EC50: 0.31 and 51 ?M, respectively). Derivative 10 on the other hand was found active against varicella zoster virus (EC50: 4.68 ?M)."],"journal":["Bioorganic & medicinal chemistry letters"],"pagination":["1970-2"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7126545"],"repository":["biostudies-literature"],"pubmed_title":["Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics."],"pmcid":["PMC7126545"],"pubmed_authors":["Andrei G","Schols D","Balzarini J","Hulpia F","Snoeck R","Van Calenbergh S"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics.","description":"A series of new nucleoside analogues based on a C-3 branched ethynyl sugar derivative as present in 3'-C-ethynylcytidine (ECyd) and -adenosine (EAdo), combined with modified purine bases was synthetized and evaluated against a broad array of viruses and tumour cell lines. The pronounced cytostatic activity of EAdo was confirmed. EAdo and its 2,6-diaminopurine analogue showed inhibitory activity against vaccinia virus (EC50: 0.31 and 51 ?M, respectively). Derivative 10 on the other hand was found active against varicella zoster virus (EC50: 4.68 ?M).","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2020-10-01T07:28:03Z","creation":"2020-05-22T16:36:59Z"},"accession":"S-EPMC7126545","cross_references":{"pubmed":["26965865"],"doi":["10.1016/j.bmcl.2016.03.005"]}}