biostudies-literatureUnknown26(8)Hulpia FA series of new nucleoside analogues based on a C-3 branched ethynyl sugar derivative as present in 3'-C-ethynylcytidine (ECyd) and -adenosine (EAdo), combined with modified purine bases was synthetized and evaluated against a broad array of viruses and tumour cell lines. The pronounced cytostatic activity of EAdo was confirmed. EAdo and its 2,6-diaminopurine analogue showed inhibitory activity against vaccinia virus (EC50: 0.31 and 51 ?M, respectively). Derivative 10 on the other hand was found active against varicella zoster virus (EC50: 4.68 ?M).Bioorganic & medicinal chemistry letters1970-2https://www.ebi.ac.uk/biostudies/studies/S-EPMC7126545biostudies-literatureExploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics.PMC7126545Andrei GSchols DBalzarini JHulpia FSnoeck RVan Calenbergh SfalseExploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics.A series of new nucleoside analogues based on a C-3 branched ethynyl sugar derivative as present in 3'-C-ethynylcytidine (ECyd) and -adenosine (EAdo), combined with modified purine bases was synthetized and evaluated against a broad array of viruses and tumour cell lines. The pronounced cytostatic activity of EAdo was confirmed. EAdo and its 2,6-diaminopurine analogue showed inhibitory activity against vaccinia virus (EC50: 0.31 and 51 ?M, respectively). Derivative 10 on the other hand was found active against varicella zoster virus (EC50: 4.68 ?M).2016-01-01T00:00:00Z2016 Apr2020-10-01T07:28:03Z2020-05-22T16:36:59ZS-EPMC71265452696586510.1016/j.bmcl.2016.03.005