{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tong SM"],"funding":["Ministry of Science and Technology of the People&apos;s Republic of China","National Natural Science Foundation of China"],"pagination":["E626"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7140403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["Non-rhythmic conidiation favors large-scale production of conidia serving as active ingredients of fungal insecticides, but its regulatory mechanism is unknown. Here, we report that two FREQUENCY (FRQ) proteins (Frq1/2) governed by a unique FRQ-interacting RNA helicase (FRH) orchestrate this valuable trait in <i>Beauveria bassiana</i>, an asexual insect-pathogenic fungus. Frq1 (964 aa) and Frq2 (583 aa) exhibited opposite expression dynamics (rhythms) in nucleus and steadily high expression levels in cytoplasm under light or in darkness no matter whether one of them was present or absent. Such opposite nuclear dynamics presented a total FRQ (pooled Frq1/2) level sufficient to persistently activate central developmental pathway in daytime and nighttime and supports continuous (non-rhythmic)"],"journal":["Cells"],"pubmed_title":["Opposite Nuclear Dynamics of Two FRH-Dominated Frequency Proteins Orchestrate Non-Rhythmic Conidiation in <i>Beauveria bassiana</i>."],"pmcid":["PMC7140403"],"funding_grant_id":["31801795","31772218","2017YFD0201202"],"pubmed_authors":["Cai Q","Wang DY","Tong SM","Ying SH","Feng MG"],"additional_accession":[]},"is_claimable":false,"name":"Opposite Nuclear Dynamics of Two FRH-Dominated Frequency Proteins Orchestrate Non-Rhythmic Conidiation in <i>Beauveria bassiana</i>.","description":"Non-rhythmic conidiation favors large-scale production of conidia serving as active ingredients of fungal insecticides, but its regulatory mechanism is unknown. Here, we report that two FREQUENCY (FRQ) proteins (Frq1/2) governed by a unique FRQ-interacting RNA helicase (FRH) orchestrate this valuable trait in <i>Beauveria bassiana</i>, an asexual insect-pathogenic fungus. Frq1 (964 aa) and Frq2 (583 aa) exhibited opposite expression dynamics (rhythms) in nucleus and steadily high expression levels in cytoplasm under light or in darkness no matter whether one of them was present or absent. Such opposite nuclear dynamics presented a total FRQ (pooled Frq1/2) level sufficient to persistently activate central developmental pathway in daytime and nighttime and supports continuous (non-rhythmic)","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2026-04-30T19:08:42.456Z","creation":"2026-04-07T16:14:44.818Z"},"accession":"S-EPMC7140403","cross_references":{"pubmed":["32151014"],"doi":["10.3390/cells9030626"]}}