{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Crofts KF"],"funding":["National Institutes of Health"],"pubmed_abstract":["The ability of T cells to sense and respond to environmental cues by altering their functional capabilities is critical for a safe and optimally protective immune response. One of the important properties that contributes to this goal is the activation set-point of the T cell. Here we report a new pathway through which TCR transgenic OT-I CD8<sup>+</sup> T cells can self-tune their activation threshold. We find that in the presence of a strong TCR engagement event there is a shift in the metabolic programming of the cell where both glycolysis and oxidative phosphorylation are significantly increased. This diverges from the switch to a predominantly glycolytic profile that would be predicted following naïve T cell activation. Our data suggest this altered metabolic program results in the pr"],"journal":["Frontiers in immunology"],"pagination":["540"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7145404"],"repository":["biostudies-literature"],"pubmed_title":["TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8<sup>+</sup> T Cell Activation Setpoint."],"pmcid":["PMC7145404"],"pubmed_authors":["Holbrook BC","Ornelles DA","Alexander-Miller MA","Soto-Pantoja DR","Crofts KF"],"additional_accession":[]},"is_claimable":false,"name":"TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8<sup>+</sup> T Cell Activation Setpoint.","description":"The ability of T cells to sense and respond to environmental cues by altering their functional capabilities is critical for a safe and optimally protective immune response. One of the important properties that contributes to this goal is the activation set-point of the T cell. Here we report a new pathway through which TCR transgenic OT-I CD8<sup>+</sup> T cells can self-tune their activation threshold. We find that in the presence of a strong TCR engagement event there is a shift in the metabolic programming of the cell where both glycolysis and oxidative phosphorylation are significantly increased. This diverges from the switch to a predominantly glycolytic profile that would be predicted following naïve T cell activation. Our data suggest this altered metabolic program results in the pr","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T07:20:42.024Z","creation":"2020-05-22T17:27:23Z"},"accession":"S-EPMC7145404","cross_references":{"pubmed":["32300344"],"doi":["10.3389/fimmu.2020.00540"]}}