{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang J"],"funding":["NHC Drug Discovery Program","Department of Science and Technology of Hubei porvince","Ministry of Science and Technology of the People's Republic of China","Ministry of Science and Technology of the People's Republic of China","National Natural Science Foundation of China"],"pagination":["987-1001"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7145789"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(5)"],"pubmed_abstract":["Aims/hypothesis
High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was rediscovered to be a 'danger signal' (alarmin) that alerts the immune system once released extracellularly. Therefore, it has been recognised contributing to the pathogenesis of autoimmune diabetes, but its exact impact on the initiation and progression of type 1 diabetes, as well as the related molecular mechanisms, are yet to be fully characterised.Methods
In the current report, we employed NOD mice as a model to dissect the impact of blocking HMGB1 on the prevention, treatment and reversal of type 1 diabetes. To study the mechanism involved, we extensively examined the characteristics of regulatory T cells (Tregs) and their related signalling pathways upon HMGB1 stimul"],"journal":["Diabetologia"],"pubmed_title":["Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability."],"pmcid":["PMC7145789"],"funding_grant_id":["91749207","2017ACA096","2017YFC1309603","2017ZX09304022-07"],"pubmed_authors":["Liu J","Li J","Zhang J","Chen L","Yu Q","Wang F","Huang K","Zhang S","Zhou Z","Zou Y","Khan F","Li Y","Wang CY","Luo J","Chen Z","Yang P","Adam BL","Sun F","Eizirik DL","Xiong F"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability.","description":"Aims/hypothesis
High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was rediscovered to be a 'danger signal' (alarmin) that alerts the immune system once released extracellularly. Therefore, it has been recognised contributing to the pathogenesis of autoimmune diabetes, but its exact impact on the initiation and progression of type 1 diabetes, as well as the related molecular mechanisms, are yet to be fully characterised.Methods
In the current report, we employed NOD mice as a model to dissect the impact of blocking HMGB1 on the prevention, treatment and reversal of type 1 diabetes. To study the mechanism involved, we extensively examined the characteristics of regulatory T cells (Tregs) and their related signalling pathways upon HMGB1 stimul","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-21T15:50:36.858Z","creation":"2020-05-22T17:13:20Z"},"accession":"S-EPMC7145789","cross_references":{"pubmed":["32072192"],"doi":["10.1007/s00125-020-05105-8"]}}