{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hanson AJ"],"funding":["NIDDK NIH HHS","NIA NIH HHS","National Institutes of Health","U.S. Department of Veterans Affairs","University of Washington Chair of Medicine Scholars Award","NIH HHS","National Institute on Aging"],"pagination":["6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7147960"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Introduction</h4>High-fat diets increase risk for Alzheimer's disease, but individuals with the risk gene APOE ε4 (E4) paradoxically have improved memory soon after high fat feeding. Little is known about how dietary lipids affect CNS lipids, especially in older adults.<h4>Objectives</h4>We analyzed the lipidomic signature of cerebrospinal fluid (CSF) in older adults who underwent both a saline and TG infusion. We further analyzed these data by E4 carrier status.<h4>Methods</h4>Older adults (n = 21, age 67.7 ± 8.6) underwent a 5-h TG and saline infusion on different days in random crossover design; lumbar CSF was collected at the end of the infusion. Lipids were extracted using dichloromethane/methanol and 13 classes of lipids analyzed using the Lipidyzer platform consisting of an AB S"],"journal":["Metabolomics : Official journal of the Metabolomic Society"],"pubmed_title":["Cerebrospinal fluid lipidomics: effects of an intravenous triglyceride infusion and apoE status."],"pmcid":["PMC7147960"],"funding_grant_id":["P30 AG049638","L30 AG043135","S10 OD021562","1S10OD021562-01","P30 DK017047","K23 AG047978","1K23AG047978-01A1"],"pubmed_authors":["Raftery D","Craft S","Banks WA","Pepin R","Hanson AJ","Bettcher LF"],"additional_accession":[]},"is_claimable":false,"name":"Cerebrospinal fluid lipidomics: effects of an intravenous triglyceride infusion and apoE status.","description":"<h4>Introduction</h4>High-fat diets increase risk for Alzheimer's disease, but individuals with the risk gene APOE ε4 (E4) paradoxically have improved memory soon after high fat feeding. Little is known about how dietary lipids affect CNS lipids, especially in older adults.<h4>Objectives</h4>We analyzed the lipidomic signature of cerebrospinal fluid (CSF) in older adults who underwent both a saline and TG infusion. We further analyzed these data by E4 carrier status.<h4>Methods</h4>Older adults (n = 21, age 67.7 ± 8.6) underwent a 5-h TG and saline infusion on different days in random crossover design; lumbar CSF was collected at the end of the infusion. Lipids were extracted using dichloromethane/methanol and 13 classes of lipids analyzed using the Lipidyzer platform consisting of an AB S","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-19T07:46:04.123Z","creation":"2025-04-19T07:46:04.123Z"},"accession":"S-EPMC7147960","cross_references":{"pubmed":["31832778"],"doi":["10.1007/s11306-019-1627-x"]}}