{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2020"],"submitter":["Bratseth V"],"funding":["Stein-Erik Hagen foundation for Clinical Heart Research, Oslo, Norway"],"pubmed_abstract":["<h4>Background</h4>Type 1 diabetes is a chronic disease including hyperglycemia and accelerated atherosclerosis, with high risk of micro- and macrovascular complications. Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis and discussed to be markers of vascular dysfunction and hypercoagulability. Limited knowledge exists on hypercoagulability in young diabetics. We aimed to investigate cMVs over a five-year period in children/adolescents with type 1 diabetes compared with controls and any associations with glycemic control and cardiovascular risk factors. We hypothesized increased shedding of cMVs in type 1 diabetes in response to vascular activation.<h4>Methods</h4>The cohort included type 1 diabetics (<i>n</i> = 40) and healthy controls (<i>"],"journal":["Journal of diabetes research"],"pagination":["7216863"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7149325"],"repository":["biostudies-literature"],"pubmed_title":["Annexin V<sup>+</sup> Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study."],"pmcid":["PMC7149325"],"pubmed_authors":["Heier M","Solheim S","Dahl-Jorgensen K","Margeirsdottir HD","Chiva-Blanch G","Arnesen H","Seljeflot I","Bratseth V"],"additional_accession":[]},"is_claimable":false,"name":"Annexin V<sup>+</sup> Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study.","description":"<h4>Background</h4>Type 1 diabetes is a chronic disease including hyperglycemia and accelerated atherosclerosis, with high risk of micro- and macrovascular complications. Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis and discussed to be markers of vascular dysfunction and hypercoagulability. Limited knowledge exists on hypercoagulability in young diabetics. We aimed to investigate cMVs over a five-year period in children/adolescents with type 1 diabetes compared with controls and any associations with glycemic control and cardiovascular risk factors. We hypothesized increased shedding of cMVs in type 1 diabetes in response to vascular activation.<h4>Methods</h4>The cohort included type 1 diabetics (<i>n</i> = 40) and healthy controls (<i>","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-06-01T12:24:31.837Z","creation":"2025-06-01T12:24:31.837Z"},"accession":"S-EPMC7149325","cross_references":{"pubmed":["32309448"],"doi":["10.1155/2020/7216863"]}}