biostudies-literatureUnknown2020Bratseth VStein-Erik Hagen foundation for Clinical Heart Research, Oslo, Norway<h4>Background</h4>Type 1 diabetes is a chronic disease including hyperglycemia and accelerated atherosclerosis, with high risk of micro- and macrovascular complications. Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis and discussed to be markers of vascular dysfunction and hypercoagulability. Limited knowledge exists on hypercoagulability in young diabetics. We aimed to investigate cMVs over a five-year period in children/adolescents with type 1 diabetes compared with controls and any associations with glycemic control and cardiovascular risk factors. We hypothesized increased shedding of cMVs in type 1 diabetes in response to vascular activation.<h4>Methods</h4>The cohort included type 1 diabetics (<i>n</i> = 40) and healthy controls (<i>Journal of diabetes research7216863https://www.ebi.ac.uk/biostudies/studies/S-EPMC7149325biostudies-literatureAnnexin V⁺ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study.PMC7149325Heier MSolheim SDahl-Jorgensen KMargeirsdottir HDChiva-Blanch GArnesen HSeljeflot IBratseth VfalseAnnexin V⁺ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study.<h4>Background</h4>Type 1 diabetes is a chronic disease including hyperglycemia and accelerated atherosclerosis, with high risk of micro- and macrovascular complications. Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis and discussed to be markers of vascular dysfunction and hypercoagulability. Limited knowledge exists on hypercoagulability in young diabetics. We aimed to investigate cMVs over a five-year period in children/adolescents with type 1 diabetes compared with controls and any associations with glycemic control and cardiovascular risk factors. We hypothesized increased shedding of cMVs in type 1 diabetes in response to vascular activation.<h4>Methods</h4>The cohort included type 1 diabetics (<i>n</i> = 40) and healthy controls (<i>2020-01-01T00:00:00Z20202025-06-01T12:24:31.837Z2025-06-01T12:24:31.837ZS-EPMC71493253230944810.1155/2020/7216863