{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ding D"],"funding":["University of Science and Technology of China","Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China","1000-Youth Talents Plan"],"pagination":["101017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7155205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(4)"],"pubmed_abstract":["Herein we demonstrate the successful application of reductive strategy in the asymmetric domino ring opening/cross-coupling reaction of prochiral cyclobutanones. Under the catalysis of a chiral nickel complex, various aryl iodide-tethered cyclobutanones were reacted with alkyl bromides as the electrophilic coupling partner, providing a variety of chiral indanones bearing a quaternary stereogenic center in highly enantioselective manner, which can be further converted to diverse benzene-fused cyclic compounds including indane, indene, dihydrocoumarin, and dihydroquinolinone. The preliminary mechanistic investigations support a mechanism involving Ni(I)-mediated enantiotopic C-C σ-bond activation of cyclobutanones as key elementary step in the catalytic cycle."],"journal":["iScience"],"pubmed_title":["Nickel-Catalyzed Asymmetric Domino Ring Opening/Cross-Coupling Reaction of Cyclobutanones via a Reductive Strategy."],"pmcid":["PMC7155205"],"funding_grant_id":["21772183","WK2060190086"],"pubmed_authors":["Dong H","Ding D","Wang C"],"additional_accession":[]},"is_claimable":false,"name":"Nickel-Catalyzed Asymmetric Domino Ring Opening/Cross-Coupling Reaction of Cyclobutanones via a Reductive Strategy.","description":"Herein we demonstrate the successful application of reductive strategy in the asymmetric domino ring opening/cross-coupling reaction of prochiral cyclobutanones. Under the catalysis of a chiral nickel complex, various aryl iodide-tethered cyclobutanones were reacted with alkyl bromides as the electrophilic coupling partner, providing a variety of chiral indanones bearing a quaternary stereogenic center in highly enantioselective manner, which can be further converted to diverse benzene-fused cyclic compounds including indane, indene, dihydrocoumarin, and dihydroquinolinone. The preliminary mechanistic investigations support a mechanism involving Ni(I)-mediated enantiotopic C-C σ-bond activation of cyclobutanones as key elementary step in the catalytic cycle.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2024-11-20T17:03:43.904Z","creation":"2020-05-22T17:22:55Z"},"accession":"S-EPMC7155205","cross_references":{"pubmed":["32289735"],"doi":["10.1016/j.isci.2020.101017"]}}