{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(7)"],"submitter":["Moor MB"],"funding":["Swiss National Science Foundation","Novartis Foundation"],"pubmed_abstract":["Mediator of cell motility 1 (MEMO1) is a ubiquitously expressed modulator of cellular responses to growth factors including FGF23 signaling, and Memo1-deficient mice share some phenotypic traits with Fgf23- or Klotho-deficient mouse models. Here, we tested whether Memo1 gene expression is regulated by calciotropic hormones or by changing the dietary mineral load. MLO-Y4 osteocyte-like cells were cultured and treated with 1,25(OH)<sub>2</sub> -vitamin D<sub>3</sub> . Wild-type C57BL/6N mice underwent treatments with 1,25(OH)<sub>2</sub> -vitamin D<sub>3</sub> , parathyroid hormone, 17β-estradiol or vehicle. Other cohorts of C57BL/6N mice were fed diets varying in calcium or phosphate content. Expression of Memo1 and control genes was assessed by qPCR. 1,25(OH)<sub>2</sub> -vitamin D<sub>3</"],"journal":["Physiological reports"],"pagination":["e14410"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7156332"],"repository":["biostudies-literature"],"pubmed_title":["Memo1 gene expression in kidney and bone is unaffected by dietary mineral load and calciotropic hormones."],"pmcid":["PMC7156332"],"pubmed_authors":["Moor MB","Bonny O"],"additional_accession":[]},"is_claimable":false,"name":"Memo1 gene expression in kidney and bone is unaffected by dietary mineral load and calciotropic hormones.","description":"Mediator of cell motility 1 (MEMO1) is a ubiquitously expressed modulator of cellular responses to growth factors including FGF23 signaling, and Memo1-deficient mice share some phenotypic traits with Fgf23- or Klotho-deficient mouse models. Here, we tested whether Memo1 gene expression is regulated by calciotropic hormones or by changing the dietary mineral load. MLO-Y4 osteocyte-like cells were cultured and treated with 1,25(OH)<sub>2</sub> -vitamin D<sub>3</sub> . Wild-type C57BL/6N mice underwent treatments with 1,25(OH)<sub>2</sub> -vitamin D<sub>3</sub> , parathyroid hormone, 17β-estradiol or vehicle. Other cohorts of C57BL/6N mice were fed diets varying in calcium or phosphate content. Expression of Memo1 and control genes was assessed by qPCR. 1,25(OH)<sub>2</sub> -vitamin D<sub>3</","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-04T22:34:27.087Z","creation":"2020-05-22T17:34:40Z"},"accession":"S-EPMC7156332","cross_references":{"pubmed":["32291966"],"doi":["10.14814/phy2.14410"]}}