{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Omar A"],"pubmed_abstract":["We screened some phytochemicals for cytotoxic activity to human cancer cells and identified Soyasapogenol-A (Snol-A) as a potent candidate anti-cancer compound. Interestingly, Soyasapogenin-I (Snin-I) was ineffective. Viability assays endorsed toxicity of Snol-A to a wide variety of cancer cells. Of note, wild type p53 deficient cancer cells (SKOV-3 and Saos-2) also showed potent growth inhibitory effect. Molecular analyses demonstrated that it targets CARF yielding transcriptional upregulation of p21<sup>WAF1</sup> (an inhibitor of cyclin-dependent kinases) and downregulation of its effector proteins, CDK2, CDK-4, Cyclin A and Cyclin D1. Targeting of CARF by Snol-A also caused (i) downregulation of pATR-Chk1 signaling leading to caspase-mediated apoptosis and (ii) inactivation of β-cateni"],"journal":["Scientific reports"],"pagination":["6323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7156697"],"repository":["biostudies-literature"],"pubmed_title":["Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells."],"pmcid":["PMC7156697"],"pubmed_authors":["Putri J","Wadhwa R","Elwakeel A","Kaul SC","Omar A","Kalra RS"],"additional_accession":[]},"is_claimable":false,"name":"Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells.","description":"We screened some phytochemicals for cytotoxic activity to human cancer cells and identified Soyasapogenol-A (Snol-A) as a potent candidate anti-cancer compound. Interestingly, Soyasapogenin-I (Snin-I) was ineffective. Viability assays endorsed toxicity of Snol-A to a wide variety of cancer cells. Of note, wild type p53 deficient cancer cells (SKOV-3 and Saos-2) also showed potent growth inhibitory effect. Molecular analyses demonstrated that it targets CARF yielding transcriptional upregulation of p21<sup>WAF1</sup> (an inhibitor of cyclin-dependent kinases) and downregulation of its effector proteins, CDK2, CDK-4, Cyclin A and Cyclin D1. Targeting of CARF by Snol-A also caused (i) downregulation of pATR-Chk1 signaling leading to caspase-mediated apoptosis and (ii) inactivation of β-cateni","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-05-29T21:15:26.094Z","creation":"2025-05-29T21:15:26.094Z"},"accession":"S-EPMC7156697","cross_references":{"pubmed":["32286347"],"doi":["10.1038/s41598-020-62953-5"]}}