{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Banerjee R"],"funding":["HHS | National Institutes of Health","NIGMS NIH HHS","Robert Turrel Endowment","National Science Foundation"],"pagination":["e00351-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7157518"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Pathogenicity islands and plasmids bear genes for pathogenesis of various <i>Escherichia coli</i> pathotypes. Although there is a basic understanding of the contribution of these virulence factors to disease, less is known about variation in regulatory networks in determining disease phenotypes. Here, we dissected a regulatory network directed by the conserved iron homeostasis regulator, ferric uptake regulator (Fur), in uropathogenic <i>E. coli</i> (UPEC) strain CFT073. Comparing anaerobic genome-scale Fur DNA binding with Fur-dependent transcript expression and protein levels of the uropathogen to that of commensal <i>E. coli</i> K-12 strain MG1655 showed that the Fur regulon of the core genome is conserved but also includes genes within the pathogenicity/genetic islands. Unexpectedly, r"],"journal":["mBio"],"pubmed_title":["Tailoring a Global Iron Regulon to a Uropathogen."],"pmcid":["PMC7157518"],"funding_grant_id":["R01 GM115894","1818303","GM108538","GM115894","P41 GM108538"],"pubmed_authors":["Perna NT","Kiley PJ","Banerjee R","Glasner JD","Welch RA","Schwartz KJ","Weisenhorn E","Myers KS","Coon JJ"],"additional_accession":[]},"is_claimable":false,"name":"Tailoring a Global Iron Regulon to a Uropathogen.","description":"Pathogenicity islands and plasmids bear genes for pathogenesis of various <i>Escherichia coli</i> pathotypes. Although there is a basic understanding of the contribution of these virulence factors to disease, less is known about variation in regulatory networks in determining disease phenotypes. Here, we dissected a regulatory network directed by the conserved iron homeostasis regulator, ferric uptake regulator (Fur), in uropathogenic <i>E. coli</i> (UPEC) strain CFT073. Comparing anaerobic genome-scale Fur DNA binding with Fur-dependent transcript expression and protein levels of the uropathogen to that of commensal <i>E. coli</i> K-12 strain MG1655 showed that the Fur regulon of the core genome is conserved but also includes genes within the pathogenicity/genetic islands. Unexpectedly, r","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2026-06-07T07:58:54.421Z","creation":"2025-06-01T03:54:25.392Z"},"accession":"S-EPMC7157518","cross_references":{"pubmed":["32209682"],"doi":["10.1128/mBio.00351-20"]}}