{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(3)"],"submitter":["Franzoni G"],"pubmed_abstract":["African swine fever (ASF) poses a severe threat to the global pig industry for which currently there is no available vaccine. The aetiological ASF virus (ASFV) has a predilection for cells of the myeloid lineage, however little is known about its interaction with polarised macrophages. This study focused on the in vitro interactions of porcine monocyte-derived un-activated (moMΦ), classically (moM1), alternatively (moM2), and IFN-a-activated macrophages with two genotype I ASFV strains: virulent 22653/14 and attenuated NH/P68. At a high multiplicity of infection, NH/P68, but not 22653/14, presented a reduced ability to infect moM1 and IFN-a-activated moMF compared to moMF. IFN-a activation resulted in a dose-dependent reduction in the proportion of ASFV-infected cells. Both strains replica"],"journal":["Pathogens (Basel, Switzerland)"],"pagination":["E209"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7157553"],"repository":["biostudies-literature"],"pubmed_title":["Comparison of Macrophage Responses to African Swine Fever Viruses Reveals that the NH/P68 Strain is Associated with Enhanced Sensitivity to Type I IFN and Cytokine Responses from Classically Activated Macrophages."],"pmcid":["PMC7157553"],"pubmed_authors":["Dei Giudici S","Modesto P","Carta T","Angioi P","Graham SP","Galleri G","Zinellu S","Ledda M","Oggiano A","Razzuoli E","Franzoni G"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of Macrophage Responses to African Swine Fever Viruses Reveals that the NH/P68 Strain is Associated with Enhanced Sensitivity to Type I IFN and Cytokine Responses from Classically Activated Macrophages.","description":"African swine fever (ASF) poses a severe threat to the global pig industry for which currently there is no available vaccine. The aetiological ASF virus (ASFV) has a predilection for cells of the myeloid lineage, however little is known about its interaction with polarised macrophages. This study focused on the in vitro interactions of porcine monocyte-derived un-activated (moMΦ), classically (moM1), alternatively (moM2), and IFN-a-activated macrophages with two genotype I ASFV strains: virulent 22653/14 and attenuated NH/P68. At a high multiplicity of infection, NH/P68, but not 22653/14, presented a reduced ability to infect moM1 and IFN-a-activated moMF compared to moMF. IFN-a activation resulted in a dose-dependent reduction in the proportion of ASFV-infected cells. Both strains replica","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2025-04-22T00:49:28.36Z","creation":"2020-05-22T18:55:11Z"},"accession":"S-EPMC7157553","cross_references":{"pubmed":["32178332"],"doi":["10.3390/pathogens9030209"]}}