biostudies-literaturePrem KNational Institute for Health Research (NIHR)Wellcome Truste261-e270https://www.ebi.ac.uk/biostudies/studies/S-EPMC7158905biostudies-literatureUnknown5(5)<h4>Background</h4>In December, 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, emerged in Wuhan, China. Since then, the city of Wuhan has taken unprecedented measures in response to the outbreak, including extended school and workplace closures. We aimed to estimate the effects of physical distancing measures on the progression of the COVID-19 epidemic, hoping to provide some insights for the rest of the world.<h4>Methods</h4>To examine how changes in population mixing have affected outbreak progression in Wuhan, we used synthetic location-specific contact patterns in Wuhan and adapted these in the presence of school closures, extended workplace closures, and a reduction in mixing in the general community. Using these matrices and the latest estimaThe Lancet. Public healthThe effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study.PMC715890516/137/10206250/Z/17/ZPR-OD-1017-20002210758/Z/18/ZDiamond CBosse NIGibbs HFunk SPearson CABvan Zandvoort KPrem KLiu YCentre for the Mathematical Modelling of Infectious Diseases COVID-19 Working GroupKucharski AJQuilty BJJarvis CIClifford SSun FGimma AAbbott SEggo RMJombart TJit MFlasche SHellewell JDavies NKlepac PEdmunds WJRosello AMunday JDRussell TWfalseThe effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study.<h4>Background</h4>In December, 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, emerged in Wuhan, China. Since then, the city of Wuhan has taken unprecedented measures in response to the outbreak, including extended school and workplace closures. We aimed to estimate the effects of physical distancing measures on the progression of the COVID-19 epidemic, hoping to provide some insights for the rest of the world.<h4>Methods</h4>To examine how changes in population mixing have affected outbreak progression in Wuhan, we used synthetic location-specific contact patterns in Wuhan and adapted these in the presence of school closures, extended workplace closures, and a reduction in mixing in the general community. Using these matrices and the latest estima2020-01-01T00:00:00Z2020 May2025-05-29T20:24:29.643Z2025-05-29T20:24:29.643ZS-EPMC71589053222065510.1016/S2468-2667(20)30073-6