biostudies-literatureUnknown11Xue X<b>Objective:</b> To investigate the cumulative live birth rates (CLBR) according to body mass index (BMI) in women undergoing their first <i>in vitro</i> fertilization (IVF). <b>Design:</b> Retrospective cohort analysis. <b>Setting:</b> An IVF clinic in a public hospital. <b>Patients:</b> This is a retrospective study of 14,782 patients undergoing their first fresh IVF cycles and subsequent frozen embryo transfers in our clinic from January 2014 to January 2017. The follow-up for CLBR continued until January 2019. Patients with a BMI <18.5 kg/m² were considered to be underweight and those with a BMI > 24 kg/m² were considered to be overweight. Patients with a BMI ≥ 28 kg/m² were considered to be obese. <b>Intervention(s):</b> None. <b>Primary Outcome Measure:</b> The primary outcome was cumulative live birth rate (CLBR). <b>Result(s):</b> This study illustrated the "inverted U shape" associations between body weight and IVF outcome (CLBR). The turning points in threshold analysis, as found by an automatic search, were BMIs of 18.5 and 30.4 kg/m². The main finding of this retrospective data analysis is that the CLBR increased in underweight women, plateaued for normal weight and overweight women with a BMI between 18.5 and 30.4 kg/m², and decreased in obese women. <b>Conclusion(s):</b> The data suggested an "inverted U shape" association between BMI and CLBR. The CLBR increases in underweight women, plateaus in normal weight and overweight women, and then decreases in obese women.Frontiers in endocrinology149https://www.ebi.ac.uk/biostudies/studies/S-EPMC7160227biostudies-literatureCumulative Live Birth Rates According to Maternal Body Mass Index After First Ovarian Stimulation for <i>in vitro</i> Fertilization: A Single Center Analysis of 14,782 Patients.PMC7160227Tian LShi WZhou DShi JZhou HZhao ZXue XfalseCumulative Live Birth Rates According to Maternal Body Mass Index After First Ovarian Stimulation for <i>in vitro</i> Fertilization: A Single Center Analysis of 14,782 Patients.<b>Objective:</b> To investigate the cumulative live birth rates (CLBR) according to body mass index (BMI) in women undergoing their first <i>in vitro</i> fertilization (IVF). <b>Design:</b> Retrospective cohort analysis. <b>Setting:</b> An IVF clinic in a public hospital. <b>Patients:</b> This is a retrospective study of 14,782 patients undergoing their first fresh IVF cycles and subsequent frozen embryo transfers in our clinic from January 2014 to January 2017. The follow-up for CLBR continued until January 2019. Patients with a BMI <18.5 kg/m² were considered to be underweight and those with a BMI > 24 kg/m² were considered to be overweight. Patients with a BMI ≥ 28 kg/m² were considered to be obese. <b>Intervention(s):</b> None. <b>Primary Outcome Measure:</b> The primary outcome was cumulative live birth rate (CLBR). <b>Result(s):</b> This study illustrated the "inverted U shape" associations between body weight and IVF outcome (CLBR). The turning points in threshold analysis, as found by an automatic search, were BMIs of 18.5 and 30.4 kg/m². The main finding of this retrospective data analysis is that the CLBR increased in underweight women, plateaued for normal weight and overweight women with a BMI between 18.5 and 30.4 kg/m², and decreased in obese women. <b>Conclusion(s):</b> The data suggested an "inverted U shape" association between BMI and CLBR. The CLBR increases in underweight women, plateaus in normal weight and overweight women, and then decreases in obese women.2020-01-01T00:00:00Z20202024-12-04T11:23:57.835Z2020-05-22T18:21:30ZS-EPMC71602273232802810.3389/fendo.2020.00149