{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Finch J"],"funding":["NIEHS NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["265-276"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7164546"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(4)"],"pubmed_abstract":["Acute and chronic exposures to particulate matter (PM<sub>2.5</sub>) air pollution increase the risk for cardiovascular disease (CVD). A hypothesized mechanism linking PM<sub>2.5</sub> exposure and CVD is the induction of endothelial dysfunction - a key step to increased CVD risk. Although PM<sub>2.5</sub> exposure is associated with endothelial dysfunction and the vasoconstrictor peptide endothelin-1 (ET-1) is upregulated in endothelial dysfunction, the effects of PM<sub>2.5</sub> on ET-1 and whether or not ET-1 mediates the downstream effects of PM<sub>2.5</sub> are unclear. In addition to examining associations between acute changes in ambient PM<sub>2.5</sub> and circulating levels of ET-1, we also looked at whether changes in ET-1 were associated with changes in markers of vascular he"],"journal":["AIMS environmental science"],"pubmed_title":["Acute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults."],"pmcid":["PMC7164546"],"funding_grant_id":["P30 GM127607","T32 ES011564","R01 ES019217","R01 HL122676","P20 GM103492","U54 HL120163"],"pubmed_authors":["Bhatnagar A","Riggs DW","Finch J","Conklin DJ","O'Toole TE","Pope CA"],"additional_accession":[]},"is_claimable":false,"name":"Acute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults.","description":"Acute and chronic exposures to particulate matter (PM<sub>2.5</sub>) air pollution increase the risk for cardiovascular disease (CVD). A hypothesized mechanism linking PM<sub>2.5</sub> exposure and CVD is the induction of endothelial dysfunction - a key step to increased CVD risk. Although PM<sub>2.5</sub> exposure is associated with endothelial dysfunction and the vasoconstrictor peptide endothelin-1 (ET-1) is upregulated in endothelial dysfunction, the effects of PM<sub>2.5</sub> on ET-1 and whether or not ET-1 mediates the downstream effects of PM<sub>2.5</sub> are unclear. In addition to examining associations between acute changes in ambient PM<sub>2.5</sub> and circulating levels of ET-1, we also looked at whether changes in ET-1 were associated with changes in markers of vascular he","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-04T07:20:25.08Z","creation":"2020-05-22T18:02:42Z"},"accession":"S-EPMC7164546","cross_references":{"pubmed":["32309625"],"doi":["10.3934/environsci.2019.6.265","10.3934/environsci.2019.4.265"]}}