biostudies-literatureFinch JNIEHS NIH HHSNHLBI NIH HHSNIGMS NIH HHS265-276https://www.ebi.ac.uk/biostudies/studies/S-EPMC7164546biostudies-literatureUnknown6(4)Acute and chronic exposures to particulate matter (PM_2.5) air pollution increase the risk for cardiovascular disease (CVD). A hypothesized mechanism linking PM_2.5 exposure and CVD is the induction of endothelial dysfunction - a key step to increased CVD risk. Although PM_2.5 exposure is associated with endothelial dysfunction and the vasoconstrictor peptide endothelin-1 (ET-1) is upregulated in endothelial dysfunction, the effects of PM_2.5 on ET-1 and whether or not ET-1 mediates the downstream effects of PM_2.5 are unclear. In addition to examining associations between acute changes in ambient PM_2.5 and circulating levels of ET-1, we also looked at whether changes in ET-1 were associated with changes in markers of vascular heAIMS environmental scienceAcute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults.PMC7164546P30 GM127607T32 ES011564R01 ES019217R01 HL122676P20 GM103492U54 HL120163Bhatnagar ARiggs DWFinch JConklin DJO'Toole TEPope CAfalseAcute exposure to air pollution is associated with novel changes in blood levels of endothelin-1 and circulating angiogenic cells in young, healthy adults.Acute and chronic exposures to particulate matter (PM_2.5) air pollution increase the risk for cardiovascular disease (CVD). A hypothesized mechanism linking PM_2.5 exposure and CVD is the induction of endothelial dysfunction - a key step to increased CVD risk. Although PM_2.5 exposure is associated with endothelial dysfunction and the vasoconstrictor peptide endothelin-1 (ET-1) is upregulated in endothelial dysfunction, the effects of PM_2.5 on ET-1 and whether or not ET-1 mediates the downstream effects of PM_2.5 are unclear. In addition to examining associations between acute changes in ambient PM_2.5 and circulating levels of ET-1, we also looked at whether changes in ET-1 were associated with changes in markers of vascular he2019-01-01T00:00:00Z20192025-04-04T07:20:25.08Z2020-05-22T18:02:42ZS-EPMC71645463230962510.3934/environsci.2019.6.26510.3934/environsci.2019.4.265