biostudies-literatureMadole JWEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSNational Institute on Alcohol Abuse and AlcoholismJacobs FoundationNIAAA NIH HHS701-718https://www.ebi.ac.uk/biostudies/studies/S-EPMC7164772biostudies-literatureUnknown7(4)Comorbidity is pervasive across psychopathological symptoms, diagnoses, and domains. Network analysis is a method for investigating symptom-level associations that underlie comorbidity, particularly through <i>bridge symptoms</i> connecting diagnostic syndromes. We applied network analyses of comorbidity to data from a population-based sample of adolescents (<i>n</i> = 849). We implemented a method for assessing nonparametric moderation of psychopathology networks to evaluate differences in network structure across levels of intelligence and emotional control. Symptoms generally clustered by clinical diagnoses, but specific between-cluster bridge connections emerged. Internalizing symptoms demonstrated unique connections with aggression symptoms of interpersonal irritability, whereas exterClinical psychological science : a journal of the Association for Psychological ScienceTesting Cold and Hot Cognitive Control as Moderators of a Network of Comorbid Psychopathology Symptoms in Adolescence.PMC7164772R21 AA023322R01 HD083613R24 HD042849P2C HD042849R21 HD081437R24HD042849R21AA023322RO1HD083613R21HD081437Grotzinger ADTucker-Drob EMMadole JWHarden PKRhemtulla MfalseTesting Cold and Hot Cognitive Control as Moderators of a Network of Comorbid Psychopathology Symptoms in Adolescence.Comorbidity is pervasive across psychopathological symptoms, diagnoses, and domains. Network analysis is a method for investigating symptom-level associations that underlie comorbidity, particularly through <i>bridge symptoms</i> connecting diagnostic syndromes. We applied network analyses of comorbidity to data from a population-based sample of adolescents (<i>n</i> = 849). We implemented a method for assessing nonparametric moderation of psychopathology networks to evaluate differences in network structure across levels of intelligence and emotional control. Symptoms generally clustered by clinical diagnoses, but specific between-cluster bridge connections emerged. Internalizing symptoms demonstrated unique connections with aggression symptoms of interpersonal irritability, whereas exter2019-01-01T00:00:00Z2019 Jul2025-04-04T07:20:26.539Z2020-10-29T16:50:30ZS-EPMC71647723230904210.1177/2167702619842466