{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sivitz WI"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["940-947"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7171946"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(5)"],"pubmed_abstract":["<h4>Objective</h4>We evaluated the effect of optimizing metformin dosing on glycemia and body weight in type 2 diabetes.<h4>Research design and methods</h4>This was a prespecified analysis of 6,823 participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) taking metformin as the sole glucose-lowering drug who completed a 4- to 14-week (mean ± SD 7.9 ± 2.4) run-in in which metformin was adjusted to 2,000 mg/day or a maximally tolerated lower dose. Participants had type 2 diabetes for <10 years and an HbA<sub>1c</sub> ≥6.8% (51 mmol/mol) while taking ≥500 mg of metformin/day. Participants also received diet and exercise counseling. The primary outcome was the change in HbA<sub>1c</sub> during run-in.<h4>Results</h4>Adjusted for duration of run-i"],"journal":["Diabetes care"],"pubmed_title":["Optimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight."],"pmcid":["PMC7171946"],"funding_grant_id":["P30 DK045735","U01 DK098246","U34-DK-088043","P30 DK079626","U01-DK-098246","UL1 TR002548","P30 DK017047","P30 DK123704","P30 DK124723","U34 DK088043"],"pubmed_authors":["Estrada L","Pucchetti B","Schield E","Aroda VR","Petrovitch H","Utzschneider KM","Rassouli N","Hollander PA","Rhothisen S","Kuechenmeister L","Ngo L","DeManbey A","Burgess E","Schnurr-Breen L","Mech M","Maher-Albertelli M","Ann Banerji M","Person S","Oropesa-Gonzalez L","Waltje A","Ballentine-Cargill K","Hurtado M","Satterwhite BM","Falck-Ytter C","Young L","Sanders C","Tsovian M","Brian Kraymer R","Montgomery BK","Howard D","Karshner T","Groessl E","Ye W","Herson M","Jenkins V","Frances S","Salam M","Kissel S","Ross A","Curtis 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Participants had type 2 diabetes for <10 years and an HbA<sub>1c</sub> ≥6.8% (51 mmol/mol) while taking ≥500 mg of metformin/day. Participants also received diet and exercise counseling. The primary outcome was the change in HbA<sub>1c</sub> during run-in.<h4>Results</h4>Adjusted for duration of run-i","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2026-05-03T08:48:28.202Z","creation":"2022-02-10T08:21:26.719Z"},"accession":"S-EPMC7171946","cross_references":{"pubmed":["32139384"],"doi":["10.2337/dc19-1769"]}}