biostudies-literatureSivitz WINCATS NIH HHSNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney Diseases940-947https://www.ebi.ac.uk/biostudies/studies/S-EPMC7171946biostudies-literatureUnknown43(5)<h4>Objective</h4>We evaluated the effect of optimizing metformin dosing on glycemia and body weight in type 2 diabetes.<h4>Research design and methods</h4>This was a prespecified analysis of 6,823 participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) taking metformin as the sole glucose-lowering drug who completed a 4- to 14-week (mean ± SD 7.9 ± 2.4) run-in in which metformin was adjusted to 2,000 mg/day or a maximally tolerated lower dose. Participants had type 2 diabetes for <10 years and an HbA_1c ≥6.8% (51 mmol/mol) while taking ≥500 mg of metformin/day. Participants also received diet and exercise counseling. The primary outcome was the change in HbA_1c during run-in.<h4>Results</h4>Adjusted for duration of run-iDiabetes careOptimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight.PMC7171946P30 DK045735U01 DK098246U34-DK-088043P30 DK079626U01-DK-098246UL1 TR002548P30 DK017047P30 DK123704P30 DK124723U34 DK088043Estrada LPucchetti BSchield EAroda VRPetrovitch HUtzschneider KMRassouli NHollander PARhothisen SKuechenmeister LNgo LDeManbey ABurgess ESchnurr-Breen LMech MMaher-Albertelli MAnn Banerji MPerson SOropesa-Gonzalez LWaltje ABallentine-Cargill KHurtado MSatterwhite BMFalck-Ytter CYoung LSanders CTsovian MBrian Kraymer RMontgomery BKHoward DKarshner TGroessl EYe WHerson MJenkins VFrances SSalam MKissel SRoss ACurtis JMMorton LYamashita DMcGill JBHenry RMorton SKirpitch AJoarder FScripsick EBoeder SPassi RAyala RHinkle NMary LChatterjee RYepes MCoe MChionh KBrown-Friday JEllis ENelson RDostou JLoveland AMartinez JBuse JBOlson DSanders-Jones CMyers JPanos EScrymgeour AAlmeida HHsia DSTamborlane WBebu IArnold KJohnson MGumpel KMagenheimer EPhillips LSMaggio CHarindhanavudhi TStephanie Raines TAlguard MMeigs JKillean TSchell KPerez MKleeberger KGoodhall LPhillips LLukin JAby-Daniel DBergenstal REl-Haqq ZMartin DMcConnell JMartin CFortmann SPMarks JHernandez SCherian AGatcomb PStevens CDushkin ACastro EPham KSoliman EZMeiners VAnne Ramey PMeiners RKringas PHillery NDiane McKee MBurge MKahn SELarkin MKrause-Steinrauf HAlarcon-Casas Wright LDeLue CTsai ECBule SHurt SKeasler LKirchhoff PYounes NBourgeois BRipley VTaddese AOsornio Walker LCook JNazarov SMcCullars SKersey KAhmann AFeinglos MNGolson DPuttnam RSibymon MSchroeder ENewgard CBGoley ACamp AGomez BMIrene Garza RVerastiqui HCraine JJHolloway LKononets MVCurtis MTran TKiker LMudaliar SSanchez DMihalcea RTrence DLFlorez HJBrantley PBarzilay JMorimoto VHollander PMishko MMWarren SBaker CBalasubramanyam AHox SHAgne AGoidel RColosimo LCostello JCuffee JLargay JFPettus JBackman MHollis BMorehead FCersosimo EKhan SAIshii RRWexler DBroyles FEGao YGabrielson DCriscola JDiaz EDuran SIacoboni JThangthaeng NSchade DSChambers BBehringer-Massera SUy ARhee CSivitz WISchneier HDouglass SFortmann SLund CWalker EJacobson MHLaura Morales APop-Busui RLuchsinger JCamp AWLorber DPrihoda JKnosp LSmith OGhazi ARhee MSmith SResnicow KThacker CRArends VKozedub ATucker LLord GLovell CMontoza AFan Jordan LTaylor WWright KCulmer DAlfred APatel CHazlett CSturgess DFattaleh BNCopeland PAbraham SPatel NGulanski BLaSalle EBethepu JWright CKimpel JBStancil KAShackelford LMcPhee GLesne LCraig JGurry LHall SGullett CGonzalez ERiera GSeaquist ERHu JGonzalez JNieto-Martinez RSasaki DCatherine Robertson MFagan Murphy AShivaswamy VMartens TAtkinson KMTillson RConcepcion TCherrington AHamilton TMofor FJosephson DHAugust PMangat Dhaliwal PRecklein CGolden SAnn White CHillard MHampe CSCoffer SZhang ZMTanukonda STan MHRodriguez MGKulow TKirkman MSHill RBeringher SLinder BXhori EDulin HFraser RTurchin AWexler DJRocchio GTiktin MBantle AKuhn AKrol ASavoye LEggleston RThomas LLLi YNathan DMGoncharova AFradkin JEnglish Jones JJones SGreenway FLSood AKolli ABoyko EJArey ASteppel-Resnick JJensen CBastawrose JElasy TAKauffman BCayford MBermudez NOAdducci JRaskin PTriplitt CEggert JRaymond EDoris Hernandez McGinnisCady NPring JBantle JAbouAssi HPark JEJackson MKochis RBurch HBShojaie AGlauber HVonder Meulen MBJosey KSahnow SLessard KKrakoff JLim JProsser LLipp SWilson PButera NMHaynes NMesimer EGuarda SSao SSprague CZhang PLipps Hogan JCanaris GMartin KBergamo KWerner AMungara RMartin SCefalu WTPalmer JPCramer BMoak CAdolphe AChong HKerr JFurst MStokes KJoshevama EAsh BSteiner SHyatt JLee MSLteif ALachin JFischer LSayyed Kassem LGarvey WTRogge MCSteiner BShao HWaguespack CKessler NDay JKuo SSeegmiller JConner TGluth JDebnam EAdams CMatwichyna MHausheer CDesouza CCarlson CValencia WMCarlson AWilson CGutt MFein WLSledge ETuncer DMGoland RRoe EBuys CJGreen JBAlbu JMadden MGRADE Research GroupIsmail-Beigi FAbdul-Ghani MBays KHiggins JRedmon BHensley SCline EAguillar DBrooks-Worrell BLowe TBurt PPark JRivera-Eschright NDeFronzo RAWillis HHerman WHSivitz WLegowski EUnderkofler CBrown NMNaik ATorgrimson-Ojerio BGriffith OPi-Sunyer FXBremer AGramzinski MAbdouch IGallivan JMDuran-Valdez EKonerza WO'Neal HFriason CCohen RMGonzalez de la Torre SGong XEvans Kreider KNewman CSaenger ADoner Lotenberg LCrandall JPBurton KHerman WThomassie AInzucchi SRasouli NMcGee PSchweiger TRiccio Veliz AKKing EPuckett CMularski KTejada JPerez-Rosas VSeipel KZimmer RPSteffes MAroda VCampbell CFuller GPirics VKumar AMather KJfalseOptimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight.<h4>Objective</h4>We evaluated the effect of optimizing metformin dosing on glycemia and body weight in type 2 diabetes.<h4>Research design and methods</h4>This was a prespecified analysis of 6,823 participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) taking metformin as the sole glucose-lowering drug who completed a 4- to 14-week (mean ± SD 7.9 ± 2.4) run-in in which metformin was adjusted to 2,000 mg/day or a maximally tolerated lower dose. Participants had type 2 diabetes for <10 years and an HbA_1c ≥6.8% (51 mmol/mol) while taking ≥500 mg of metformin/day. Participants also received diet and exercise counseling. The primary outcome was the change in HbA_1c during run-in.<h4>Results</h4>Adjusted for duration of run-i2020-01-01T00:00:00Z2020 May2026-05-03T08:48:28.202Z2022-02-10T08:21:26.719ZS-EPMC71719463213938410.2337/dc19-1769