{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(1)"],"submitter":["Chu H"],"pubmed_abstract":["<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted from person to person and, in 2 months, has caused more than 82 000 laboratory-confirmed cases of coronavirus disease 2019 (COVID-19) and 2800 deaths in 46 countries. The total number of cases and deaths has surpassed that of the 2003 severe acute respiratory syndrome coronavirus (SARS-CoV). Although both COVID-19 and severe acute respiratory syndrome (SARS) manifest as pneumonia, COVID-19 is associated with apparently more efficient transmission, fewer cases of diarrhoea, increased mental confusion, and a lower crude fatality rate. However, the underlying virus-host interactive characteristics conferring these observations on trans"],"journal":["The Lancet. Microbe"],"pagination":["e14-e23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7173822"],"repository":["biostudies-literature"],"pubmed_title":["Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study."],"pmcid":["PMC7173822"],"pubmed_authors":["Cai JP","Tsoi HW","Lung DC","Chu AW","Chan WM","Chan KH","Shuai H","Chik KK","Ip JD","Hou Y","To KK","Tsang OT","Chu H","Yip CC","Wang Y","Chai Y","Zhou J","Yuan S","Chan JF","Yuen TT","Fung AY","Yang D","Hu B","Huang X","Zhang X","Tsang JO","Yuen KY","Kok KH"],"additional_accession":[]},"is_claimable":false,"name":"Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study.","description":"<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted from person to person and, in 2 months, has caused more than 82 000 laboratory-confirmed cases of coronavirus disease 2019 (COVID-19) and 2800 deaths in 46 countries. The total number of cases and deaths has surpassed that of the 2003 severe acute respiratory syndrome coronavirus (SARS-CoV). Although both COVID-19 and severe acute respiratory syndrome (SARS) manifest as pneumonia, COVID-19 is associated with apparently more efficient transmission, fewer cases of diarrhoea, increased mental confusion, and a lower crude fatality rate. However, the underlying virus-host interactive characteristics conferring these observations on trans","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2026-05-01T22:25:25.885Z","creation":"2025-05-29T21:15:18.237Z"},"accession":"S-EPMC7173822","cross_references":{"pubmed":["32835326"],"doi":["10.1016/S2666-5247(20)30004-5"]}}