{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bakker JP"],"funding":["NHLBI NIH HHS"],"pagination":["474-483"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7175977"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(4)"],"pubmed_abstract":["<b>Rationale:</b> Although both type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are independently recognized as risk factors for cardiovascular disease, little is known about their interaction.<b>Objectives:</b> We hypothesized that T2DM and OSA act synergistically to increase vascular risk, and that treatment of OSA would improve vascular reactivity in patients with T2DM plus OSA.<b>Methods:</b> Cross-sectional study of 141 adults with T2DM, OSA, T2DM plus OSA, and control subjects, followed by a 3-month, parallel-arm, randomized, placebo-controlled trial comparing active and sham continuous positive airway pressure (CPAP) in 53 adults with T2DM plus OSA. Endothelium-dependent macro- and microvascular reactivity (flow-mediated dilation [FMD] of the brachial artery and ac"],"journal":["Annals of the American Thoracic Society"],"pubmed_title":["The Effect of Continuous Positive Airway Pressure on Vascular Function and Cardiac Structure in Diabetes and Sleep Apnea. A Randomized Controlled Trial."],"pmcid":["PMC7175977"],"funding_grant_id":["T32 HL134632","R01 HL110350","K24 HL127307"],"pubmed_authors":["Bakker JP","Hudson M","Baltzis D","Chan RH","Malhotra A","Patel SR","Veves A","Tecilazich F","Manning WJ","Wallace ML","Neilan TG"],"additional_accession":[]},"is_claimable":false,"name":"The Effect of Continuous Positive Airway Pressure on Vascular Function and Cardiac Structure in Diabetes and Sleep Apnea. A Randomized Controlled Trial.","description":"<b>Rationale:</b> Although both type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are independently recognized as risk factors for cardiovascular disease, little is known about their interaction.<b>Objectives:</b> We hypothesized that T2DM and OSA act synergistically to increase vascular risk, and that treatment of OSA would improve vascular reactivity in patients with T2DM plus OSA.<b>Methods:</b> Cross-sectional study of 141 adults with T2DM, OSA, T2DM plus OSA, and control subjects, followed by a 3-month, parallel-arm, randomized, placebo-controlled trial comparing active and sham continuous positive airway pressure (CPAP) in 53 adults with T2DM plus OSA. Endothelium-dependent macro- and microvascular reactivity (flow-mediated dilation [FMD] of the brachial artery and ac","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2026-05-02T00:33:09.55Z","creation":"2022-02-10T13:43:54.421Z"},"accession":"S-EPMC7175977","cross_references":{"pubmed":["31922899"],"doi":["10.1513/AnnalsATS.201905-378OC","10.1513/annalsats.201905-378oc"]}}