biostudies-literatureBakker JPNHLBI NIH HHS474-483https://www.ebi.ac.uk/biostudies/studies/S-EPMC7175977biostudies-literatureUnknown17(4)<b>Rationale:</b> Although both type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are independently recognized as risk factors for cardiovascular disease, little is known about their interaction.<b>Objectives:</b> We hypothesized that T2DM and OSA act synergistically to increase vascular risk, and that treatment of OSA would improve vascular reactivity in patients with T2DM plus OSA.<b>Methods:</b> Cross-sectional study of 141 adults with T2DM, OSA, T2DM plus OSA, and control subjects, followed by a 3-month, parallel-arm, randomized, placebo-controlled trial comparing active and sham continuous positive airway pressure (CPAP) in 53 adults with T2DM plus OSA. Endothelium-dependent macro- and microvascular reactivity (flow-mediated dilation [FMD] of the brachial artery and acAnnals of the American Thoracic SocietyThe Effect of Continuous Positive Airway Pressure on Vascular Function and Cardiac Structure in Diabetes and Sleep Apnea. A Randomized Controlled Trial.PMC7175977T32 HL134632R01 HL110350K24 HL127307Bakker JPHudson MBaltzis DChan RHMalhotra APatel SRVeves ATecilazich FManning WJWallace MLNeilan TGfalseThe Effect of Continuous Positive Airway Pressure on Vascular Function and Cardiac Structure in Diabetes and Sleep Apnea. A Randomized Controlled Trial.<b>Rationale:</b> Although both type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are independently recognized as risk factors for cardiovascular disease, little is known about their interaction.<b>Objectives:</b> We hypothesized that T2DM and OSA act synergistically to increase vascular risk, and that treatment of OSA would improve vascular reactivity in patients with T2DM plus OSA.<b>Methods:</b> Cross-sectional study of 141 adults with T2DM, OSA, T2DM plus OSA, and control subjects, followed by a 3-month, parallel-arm, randomized, placebo-controlled trial comparing active and sham continuous positive airway pressure (CPAP) in 53 adults with T2DM plus OSA. Endothelium-dependent macro- and microvascular reactivity (flow-mediated dilation [FMD] of the brachial artery and ac2020-01-01T00:00:00Z2020 Apr2026-05-02T00:33:09.55Z2022-02-10T13:43:54.421ZS-EPMC71759773192289910.1513/AnnalsATS.201905-378OC10.1513/annalsats.201905-378oc