biostudies-literature00550Unknown8Guo J<i>Ganoderma</i> fungi have long been used as functional foods and traditional medicines in Asian countries. <i>Ganoderma ahmadii</i> is one of the main species of <i>Ganoderma</i> fungi distributed in Hainan province of China, the fruiting bodies of which have been used in folk to lower blood sugar for a long time. A chemical investigation of the fruiting bodies of <i>Ganoderma ahmadii</i> led to the isolation of seven new meroterpenoids, named ganoduriporols F-L <b>(1-7)</b>. The chemical structures of the compounds were elucidated by spectroscopic data including HRESIMS and 2D NMR. Compounds <b>5-7</b> represent the first examples of ganoduriporol-type meroterpenoids bearing oxepane rings in their skeletons. Compounds <b>1-4</b> showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) comparable to the positive control Na₃VO₄, with IC₅₀ values of 17, 20, 19, and 23 μM, respectively.Frontiers in chemistry279https://www.ebi.ac.uk/biostudies/studies/S-EPMC7176929biostudies-literatureMeroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies of <i>Ganoderma ahmadii</i>.PMC7176929Ma QGuo JKong FXie QZhang RWu YZhao YDai H55falseMeroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies of <i>Ganoderma ahmadii</i>.<i>Ganoderma</i> fungi have long been used as functional foods and traditional medicines in Asian countries. <i>Ganoderma ahmadii</i> is one of the main species of <i>Ganoderma</i> fungi distributed in Hainan province of China, the fruiting bodies of which have been used in folk to lower blood sugar for a long time. A chemical investigation of the fruiting bodies of <i>Ganoderma ahmadii</i> led to the isolation of seven new meroterpenoids, named ganoduriporols F-L <b>(1-7)</b>. The chemical structures of the compounds were elucidated by spectroscopic data including HRESIMS and 2D NMR. Compounds <b>5-7</b> represent the first examples of ganoduriporol-type meroterpenoids bearing oxepane rings in their skeletons. Compounds <b>1-4</b> showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) comparable to the positive control Na₃VO₄, with IC₅₀ values of 17, 20, 19, and 23 μM, respectively.2020-01-01T00:00:00Z20202024-11-10T03:27:16.723Z2020-05-22T19:19:12ZS-EPMC71769293237358510.3389/fchem.2020.00279