biostudies-literatureUnknown25(7)Di Gaspero MPolyphenols are an important constituent of wines and they are largely studied due to their antioxidant properties and for their effects on wine quality and stability, which is also related to their capacity to bind to proteins. The effects of some selected polyphenols, including procyanidins B1 and B2, tannic acid, quercetin, and rutin, as well as those of a total white wine procyanidin extract on the conformational properties of the major wine protein VVTL1 (<i>Vitis vinifera</i> Thaumatin-Like-1) were investigated by Synchrotron Radiation Circular Dichroism (SRCD). Results showed that VVTL1 interacts with polyphenols as demonstrated by the changes in the secondary (far-UV) and tertiary (near-UV) structures, which were differently affected by different polyphenols. Additionally, polyphenMolecules (Basel, Switzerland)E1646https://www.ebi.ac.uk/biostudies/studies/S-EPMC7180857biostudies-literatureThe Secondary Structure of a Major Wine Protein is Modified upon Interaction with Polyphenols.PMC7180857Hussain RMarangon MDi Gaspero MHonisch CCurioni ARuzza PVincenzi SSiligardi GBiondi BfalseThe Secondary Structure of a Major Wine Protein is Modified upon Interaction with Polyphenols.Polyphenols are an important constituent of wines and they are largely studied due to their antioxidant properties and for their effects on wine quality and stability, which is also related to their capacity to bind to proteins. The effects of some selected polyphenols, including procyanidins B1 and B2, tannic acid, quercetin, and rutin, as well as those of a total white wine procyanidin extract on the conformational properties of the major wine protein VVTL1 (<i>Vitis vinifera</i> Thaumatin-Like-1) were investigated by Synchrotron Radiation Circular Dichroism (SRCD). Results showed that VVTL1 interacts with polyphenols as demonstrated by the changes in the secondary (far-UV) and tertiary (near-UV) structures, which were differently affected by different polyphenols. Additionally, polyphen2020-01-01T00:00:00Z2020 Apr2026-05-04T16:47:57.521Z2020-05-22T18:55:59ZS-EPMC71808573226010410.3390/molecules25071646