biostudies-literatureVerdugo-Fuentes AConsejo Nacional de Ciencia y Tecnologíae00721-19https://www.ebi.ac.uk/biostudies/studies/S-EPMC7186460biostudies-literatureUnknown202(10)In bacterial populations, quorum sensing (QS) systems participate in the regulation of specialization processes and regulate collective behaviors that mediate interactions and allow survival of the species. In Gram-positive bacteria, QS systems of the RRNPP family (Rgg, Rap, NprR, PlcR, and PrgX) consist of intracellular receptors and their cognate signaling peptides. Two of these receptors, Rap and NprR, have regained attention in Bacillus subtilis and the Bacillus cereus group. Some Rap proteins, such as RapH and Rap60, are multifunctional and/or redundant in function, linking the specialization processes of sporulation and competence, as well as global expression changes in the transition phase in B. subtilis NprR, an evolutionary intermediate between Rap and RRNPP transcriptional activJournal of bacteriologyMultiple and Overlapping Functions of Quorum Sensing Proteins for Cell Specialization in Bacillus Species.PMC7186460267837de la Torre MVerdugo-Fuentes ARocha JGastelum GfalseMultiple and Overlapping Functions of Quorum Sensing Proteins for Cell Specialization in Bacillus Species.In bacterial populations, quorum sensing (QS) systems participate in the regulation of specialization processes and regulate collective behaviors that mediate interactions and allow survival of the species. In Gram-positive bacteria, QS systems of the RRNPP family (Rgg, Rap, NprR, PlcR, and PrgX) consist of intracellular receptors and their cognate signaling peptides. Two of these receptors, Rap and NprR, have regained attention in Bacillus subtilis and the Bacillus cereus group. Some Rap proteins, such as RapH and Rap60, are multifunctional and/or redundant in function, linking the specialization processes of sporulation and competence, as well as global expression changes in the transition phase in B. subtilis NprR, an evolutionary intermediate between Rap and RRNPP transcriptional activ2020-01-01T00:00:00Z2020 Apr2025-06-01T12:00:52.243Z2025-06-01T12:00:52.243ZS-EPMC71864603207109610.1128/JB.00721-1910.1128/jb.00721-19