biostudies-literaturePravdivtsev ANDFG-RFBREmmy Noether Program "metabolic and molecular MR"research training circle "materials for brain"European Regional Development Fund (ERDF)Cluster of Excellence "precision medicine in inflammation"German Federal Ministry of Education and Research (BMBF)Zukunftsprogramm Wirtschaft of Schleswig-Holsteine:MedKiel University667-672https://www.ebi.ac.uk/biostudies/studies/S-EPMC7187451biostudies-literatureUnknown21(7)Nuclear Magnetic Resonance (NMR) is an intriguing quantum-mechanical effect that is used for routine medical diagnostics and chemical analysis alike. Numerous advancements have contributed to the success of the technique, including hyperpolarized contrast agents that enable real-time imaging of metabolism in vivo. Herein, we report the finding of an NMR radio amplification by stimulated emission of radiation (RASER), which continuously emits 1 H NMR signal for more than 10 min. Using parahydrogen induced hyperpolarization (PHIP) with 50 % para-hydrogen, we demonstrated the effect at 600 MHz but expect that it is functional across a wide range of frequencies, e.g. 101 -103  MHz. PHIP-RASER occurs spontaneously or can be triggered with a standard NMR excitation. Full chemical shift resolution was maintained, and a linewidth of 0.6 ppb was achieved. The effect was reproduced by simulations using a weakly coupled, two spin- 1/2 system. All devices used were standard issue, such that the effect can be reproduced by any NMR lab worldwide with access to liquid nitrogen for producing parahydrogen.Chemphyschem : a European journal of chemical physics and physical chemistryContinuous Radio Amplification by Stimulated Emission of Radiation using Parahydrogen Induced Polarization (PHIP-RASER) at 14 Tesla.PMC7187451GRK 2154/1-20191267122-09-0534604/2-24604/3-101ZX1915C19-53-12013Pravdivtsev ANSonnichsen FDHovener JBfalseContinuous Radio Amplification by Stimulated Emission of Radiation using Parahydrogen Induced Polarization (PHIP-RASER) at 14 Tesla.Nuclear Magnetic Resonance (NMR) is an intriguing quantum-mechanical effect that is used for routine medical diagnostics and chemical analysis alike. Numerous advancements have contributed to the success of the technique, including hyperpolarized contrast agents that enable real-time imaging of metabolism in vivo. Herein, we report the finding of an NMR radio amplification by stimulated emission of radiation (RASER), which continuously emits 1 H NMR signal for more than 10 min. Using parahydrogen induced hyperpolarization (PHIP) with 50 % para-hydrogen, we demonstrated the effect at 600 MHz but expect that it is functional across a wide range of frequencies, e.g. 101 -103  MHz. PHIP-RASER occurs spontaneously or can be triggered with a standard NMR excitation. Full chemical shift resolution was maintained, and a linewidth of 0.6 ppb was achieved. The effect was reproduced by simulations using a weakly coupled, two spin- 1/2 system. All devices used were standard issue, such that the effect can be reproduced by any NMR lab worldwide with access to liquid nitrogen for producing parahydrogen.2020-01-01T00:00:00Z2020 Apr2024-11-08T12:16:31.614Z2020-05-22T18:36:58ZS-EPMC71874513189839310.1002/cphc.201901056