biostudies-literatureLorenzo PMInstituto de Salud Carlos III245https://www.ebi.ac.uk/biostudies/studies/S-EPMC7191069biostudies-literatureUnknown11The methylation levels of <i>ZNF577</i> in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of <i>ZNF577</i> depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of <i>ZNF577</i> of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [<i>n</i> = 90; <i>n</i> = 64 (71.1%) overweight/obesity and <i>n</i> = 26 (28.9%) normal-weight] and paired tumor tFrontiers in endocrinology<i>ZNF577</i> Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet.PMC7191069JR17/00016PI17/01287CP17/00088Crujeiras ABMacias-Gonzalez MCasanueva FFLorenzo PMSandoval JCarreira MCCueva JLopez-Lopez RIzquierdo AGDiaz-Lagares Afalse<i>ZNF577</i> Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet.The methylation levels of <i>ZNF577</i> in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of <i>ZNF577</i> depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of <i>ZNF577</i> of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [<i>n</i> = 90; <i>n</i> = 64 (71.1%) overweight/obesity and <i>n</i> = 26 (28.9%) normal-weight] and paired tumor t2020-01-01T00:00:00Z20202026-05-06T21:40:18.664Z2026-04-07T22:22:04.323ZS-EPMC71910693239094810.3389/fendo.2020.00245