{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dadonaite B"],"funding":["Medical Research Council","NHLBI NIH HHS","NHGRI NIH HHS","Wellcome Trust","NIGMS NIH HHS","Biotechnology and Biological Sciences Research Council"],"pagination":["1781-1789"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7191640"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(11)"],"pubmed_abstract":["Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are packaged together into a single virus particle. The structure of viral RNA is believed to play a role in assembling the different vRNPs into budding virions<sup>1-8</sup> and in directing reassortment between IAVs<sup>9</sup>. Reassortment between established human IAVs and IAVs harboured in the animal reservoir can lead to the emergence of pandemic influenza strains to which there is little pre-existing immunity in the human population<sup>10,11</sup>. While previous studies have revealed the overall organization of the proteins within vRNPs, characterization of viral RNA structure "],"journal":["Nature microbiology"],"pubmed_title":["The structure of the influenza A virus genome."],"pmcid":["PMC7191640"],"funding_grant_id":["R01 HL111527","MR/R009945/1","R01 GM101237","105399/Z/14/Z","BB/M011224/1","R01 GM126554","R01 HG008133","MR/K000241/1"],"pubmed_authors":["Fodor E","Dadonaite B","Rockman S","Laederach A","Trifkovic S","Knight ML","Gilbertson B","Brown LE","Bauer DLV"],"additional_accession":[]},"is_claimable":false,"name":"The structure of the influenza A virus genome.","description":"Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are packaged together into a single virus particle. The structure of viral RNA is believed to play a role in assembling the different vRNPs into budding virions<sup>1-8</sup> and in directing reassortment between IAVs<sup>9</sup>. Reassortment between established human IAVs and IAVs harboured in the animal reservoir can lead to the emergence of pandemic influenza strains to which there is little pre-existing immunity in the human population<sup>10,11</sup>. While previous studies have revealed the overall organization of the proteins within vRNPs, characterization of viral RNA structure ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-05-04T16:57:47.784Z","creation":"2020-10-29T14:05:42Z"},"accession":"S-EPMC7191640","cross_references":{"pubmed":["31332385"],"doi":["10.1038/s41564-019-0513-7"]}}