{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(12)"],"submitter":["Wang J"],"pubmed_abstract":["<b>Rationale</b>: Rheumatoid arthritis (RA) is a prototype of inflammatory arthritis in which synovial fibroblasts (SFs) play key roles in cartilage and bone destruction through tumor-like proliferation, migration, invasion and inflammation. This study aimed to research forkhead box protein C1 (FoxC1) and microRNA (miR)-141-3p, which modulate pathological changes in the synovial membrane, to find possible strategies for treating RA. <b>Methods</b>: FoxC1, β-catenin and miR-141-3p gene expression in synovial tissues and SFs was quantified by real-time PCR; FoxC1 and β-catenin protein levels were evaluated by immunohistochemistry, immunofluorescence, and Western blotting. We transiently transfected human SFs with FoxC1 and β-catenin overexpression and silencing vectors and assessed prolifera"],"journal":["Theranostics"],"pagination":["5412-5434"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7196314"],"repository":["biostudies-literature"],"pubmed_title":["Identification of a novel microRNA-141-3p/Forkhead box C1/β-catenin axis associated with rheumatoid arthritis synovial fibroblast function in vivo and in vitro."],"pmcid":["PMC7196314"],"pubmed_authors":["Lu M","Li Y","Gao M","Zhang H","Gao W","Wang X","Wang Y","Chang J","Wang J","Yin L","Liu W","Yin Z"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a novel microRNA-141-3p/Forkhead box C1/β-catenin axis associated with rheumatoid arthritis synovial fibroblast function in vivo and in vitro.","description":"<b>Rationale</b>: Rheumatoid arthritis (RA) is a prototype of inflammatory arthritis in which synovial fibroblasts (SFs) play key roles in cartilage and bone destruction through tumor-like proliferation, migration, invasion and inflammation. This study aimed to research forkhead box protein C1 (FoxC1) and microRNA (miR)-141-3p, which modulate pathological changes in the synovial membrane, to find possible strategies for treating RA. <b>Methods</b>: FoxC1, β-catenin and miR-141-3p gene expression in synovial tissues and SFs was quantified by real-time PCR; FoxC1 and β-catenin protein levels were evaluated by immunohistochemistry, immunofluorescence, and Western blotting. We transiently transfected human SFs with FoxC1 and β-catenin overexpression and silencing vectors and assessed prolifera","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T19:05:03.321Z","creation":"2020-05-22T19:27:07Z"},"accession":"S-EPMC7196314","cross_references":{"pubmed":["32373221"],"doi":["10.7150/thno.45214"]}}