biostudies-literatureShull LCNIDCR NIH HHSNINDS NIH HHSNational Institutes of Health132-144https://www.ebi.ac.uk/biostudies/studies/S-EPMC7198358biostudies-literatureUnknown461(2)The formation of the craniofacial skeleton is a highly dynamic process that requires proper orchestration of various cellular processes in cranial neural crest cell (cNCC) development, including cell migration, proliferation, differentiation, polarity and cell death. Alterations that occur during cNCC development result in congenital birth defects and craniofacial abnormalities such as cleft lip with or without cleft palate. While the gene regulatory networks facilitating neural crest development have been extensively studied, the epigenetic mechanisms by which these pathways are activated or repressed in a temporal and spatially regulated manner remain largely unknown. Chromatin modifiers can precisely modify gene expression through a variety of mechanisms including histone modifications Developmental biologyThe conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.PMC7198358P30 NS048154R01 DE024034F32 DE029099Shull LCGoyama SArtinger KBKurokawa MMenzel JSen RfalseThe conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.The formation of the craniofacial skeleton is a highly dynamic process that requires proper orchestration of various cellular processes in cranial neural crest cell (cNCC) development, including cell migration, proliferation, differentiation, polarity and cell death. Alterations that occur during cNCC development result in congenital birth defects and craniofacial abnormalities such as cleft lip with or without cleft palate. While the gene regulatory networks facilitating neural crest development have been extensively studied, the epigenetic mechanisms by which these pathways are activated or repressed in a temporal and spatially regulated manner remain largely unknown. Chromatin modifiers can precisely modify gene expression through a variety of mechanisms including histone modifications 2020-01-01T00:00:00Z2020 May2025-04-05T10:07:36.487Z2025-02-19T03:42:00.481ZS-EPMC71983583204437910.1016/j.ydbio.2020.02.006