{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li J"],"funding":["National Natural Science Foundation of China"],"pagination":["e00113-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7199404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["94(10)"],"pubmed_abstract":["Respiratory syncytial virus (RSV) is an enveloped RNA virus which is responsible for approximately 80% of lower respiratory tract infections in children. Current lines of evidence have supported the functional involvement of long noncoding RNA (lncRNA) in many viral infectious diseases. However, the overall biological effect and clinical role of lncRNAs in RSV infection remain unclear. In this study, lncRNAs related to respiratory virus infection were obtained from the lncRNA database, and we collected 144 clinical sputum specimens to identify lncRNAs related to RSV infection. Quantitative PCR (qPCR) detection indicated that the expression of lncRNA negative regulator of antiviral response (NRAV) in RSV-positive patients was significantly lower than that in uninfected patients, but lncRNA "],"journal":["Journal of virology"],"pubmed_title":["Long Noncoding RNA NRAV Promotes Respiratory Syncytial Virus Replication by Targeting the MicroRNA miR-509-3p/Rab5c Axis To Regulate Vesicle Transportation."],"pmcid":["PMC7199404"],"funding_grant_id":["31770971","81802014"],"pubmed_authors":["Sun M","Li J","Ma C","Liang W","Wang X","Gao X","Li M","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Long Noncoding RNA NRAV Promotes Respiratory Syncytial Virus Replication by Targeting the MicroRNA miR-509-3p/Rab5c Axis To Regulate Vesicle Transportation.","description":"Respiratory syncytial virus (RSV) is an enveloped RNA virus which is responsible for approximately 80% of lower respiratory tract infections in children. Current lines of evidence have supported the functional involvement of long noncoding RNA (lncRNA) in many viral infectious diseases. However, the overall biological effect and clinical role of lncRNAs in RSV infection remain unclear. In this study, lncRNAs related to respiratory virus infection were obtained from the lncRNA database, and we collected 144 clinical sputum specimens to identify lncRNAs related to RSV infection. Quantitative PCR (qPCR) detection indicated that the expression of lncRNA negative regulator of antiviral response (NRAV) in RSV-positive patients was significantly lower than that in uninfected patients, but lncRNA ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2026-04-08T02:33:28.949Z","creation":"2020-05-23T07:11:22Z"},"accession":"S-EPMC7199404","cross_references":{"pubmed":["32102886"],"doi":["10.1128/JVI.00113-20"]}}