biostudies-literatureCoffey MJAustralian Government Department of Education and TrainingNational Heart Foundation of AustraliaCommonwealth FundUniversity of New South WalesSydney Children's Hospital Foundatione033916https://www.ebi.ac.uk/biostudies/studies/S-EPMC7200033biostudies-literatureUnknown10(4)<h4>Introduction</h4>Chronic gastrointestinal and respiratory conditions of childhood can have long-lasting physical, psychosocial and economic effects on children and their families. Alterations in diet and intestinal and respiratory microbiomes may have important implications for physical and psychosocial health. Diet influences the intestinal microbiome and should be considered when exploring disease-specific alterations. The concepts of gut-brain and gut-lung axes provide novel perspectives for examining chronic childhood disease(s). We established the 'Evaluating the Alimentary and Respiratory Tracts in Health and disease' (EARTH) research programme to provide a structured, holistic evaluation of children with chronic gastrointestinal and/or respiratBMJ openEvaluating the Alimentary and Respiratory Tracts in Health and disease (EARTH) research programme: a protocol for prospective, longitudinal, controlled, observational studies in children with chronic disease at an Australian tertiary paediatric hospital.PMC7200033Australian Postgraduate Award - Dr Michael CoffeyFuture Leader Fellowship (101229) - A/Prof NadinePhD Scholarship - Dr Michael Coffey2018-2019 Harkness Fellowship in Health Care PolicIndependent Learning Project / Honours Scheme, FacCoffey MJMcKay IRKasparian NAAdams SChuang SStelzer-Braid SOoi CYDoumit MKatz TWaters SAThomas TJaffe AfalseEvaluating the Alimentary and Respiratory Tracts in Health and disease (EARTH) research programme: a protocol for prospective, longitudinal, controlled, observational studies in children with chronic disease at an Australian tertiary paediatric hospital.<h4>Introduction</h4>Chronic gastrointestinal and respiratory conditions of childhood can have long-lasting physical, psychosocial and economic effects on children and their families. Alterations in diet and intestinal and respiratory microbiomes may have important implications for physical and psychosocial health. Diet influences the intestinal microbiome and should be considered when exploring disease-specific alterations. The concepts of gut-brain and gut-lung axes provide novel perspectives for examining chronic childhood disease(s). We established the 'Evaluating the Alimentary and Respiratory Tracts in Health and disease' (EARTH) research programme to provide a structured, holistic evaluation of children with chronic gastrointestinal and/or respirat2020-01-01T00:00:00Z2020 Apr2026-05-07T04:41:38.658Z2020-05-22T19:29:36ZS-EPMC72000333229577410.1136/bmjopen-2019-033916