biostudies-literatureUnknown12(8)Mercurio LPsoriasis is a chronic Th1/Th17 lymphocytes-mediated inflammatory skin disease, in which epidermal keratinocytes exhibit a peculiar senescent state, resistance to apoptosis and the acquisition of senescence-associated secretory phenotype (SASP). SASP consists of the release of soluble factors, including IGFBPs, that exert extracellular and intracellular functions in IGF-dependent or independent manner.In this report, we investigated the expression and function of IGFBP2 in senescent keratinocytes isolated from the skin of patients with plaque psoriasis. We found that IGFBP2 is aberrantly expressed and released by these cells <i>in vivo</i>, as well as <i>in vitro</i> in keratinocyte cultures undergoing progressive senescence, and it associates with the cyclin-dependent kinase inhibitors p2Aging6823-6851https://www.ebi.ac.uk/biostudies/studies/S-EPMC7202509biostudies-literatureIntracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21.PMC7202509Lulli DDellambra EPastore SValente CCarbone MLPallotta SScarponi CGirolomoni GAlbanesi CMadonna SMascia FMercurio LMorelli MfalseIntracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21.Psoriasis is a chronic Th1/Th17 lymphocytes-mediated inflammatory skin disease, in which epidermal keratinocytes exhibit a peculiar senescent state, resistance to apoptosis and the acquisition of senescence-associated secretory phenotype (SASP). SASP consists of the release of soluble factors, including IGFBPs, that exert extracellular and intracellular functions in IGF-dependent or independent manner.In this report, we investigated the expression and function of IGFBP2 in senescent keratinocytes isolated from the skin of patients with plaque psoriasis. We found that IGFBP2 is aberrantly expressed and released by these cells <i>in vivo</i>, as well as <i>in vitro</i> in keratinocyte cultures undergoing progressive senescence, and it associates with the cyclin-dependent kinase inhibitors p22020-01-01T00:00:00Z2020 Apr2025-06-01T03:30:13.458Z2025-06-01T03:30:13.458ZS-EPMC72025093230228810.18632/aging.103045