biostudies-literatureEpalza CFoundation Vésale, Belgium45-52https://www.ebi.ac.uk/biostudies/studies/S-EPMC7206330biostudies-literatureUnknown59(1)As infants with proven viral infection present lower risk of bacterial infection, we evaluated how molecular methods detecting viruses on respiratory secretions could contribute to etiological diagnostic of these febrile episodes. From November 2010 to May 2011, we enrolled all febrile infants <90 days presenting to emergency room. Standard workup included viral rapid antigenic test and viral culture on nasopharyngeal aspirate. Samples negative by rapid testing were tested by molecular methods. From 208 febrile episodes (198 infants) with standard techniques, rate of documented microbiological etiology was 13% at emergency department, 47% during hospitalization, and 64% with viral cultures. Molecular methods increased microbiologically documented etiology rate by 12%, to 76%. Contribution Clinical pediatricsRole of Viral Molecular Panels in Diagnosing the Etiology of Fever in Infants Younger Than 3 Months.PMC72063302010Levy JBusson LVandenberg OHallin MDe Backer PEpalza CDebulpaep SfalseRole of Viral Molecular Panels in Diagnosing the Etiology of Fever in Infants Younger Than 3 Months.As infants with proven viral infection present lower risk of bacterial infection, we evaluated how molecular methods detecting viruses on respiratory secretions could contribute to etiological diagnostic of these febrile episodes. From November 2010 to May 2011, we enrolled all febrile infants <90 days presenting to emergency room. Standard workup included viral rapid antigenic test and viral culture on nasopharyngeal aspirate. Samples negative by rapid testing were tested by molecular methods. From 208 febrile episodes (198 infants) with standard techniques, rate of documented microbiological etiology was 13% at emergency department, 47% during hospitalization, and 64% with viral cultures. Molecular methods increased microbiologically documented etiology rate by 12%, to 76%. Contribution 2020-01-01T00:00:00Z2020 Jan2025-04-19T11:50:44.829Z2020-06-07T07:03:03ZS-EPMC72063303170980110.1177/0009922819884582