{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ebrahimpour-Malekshah R"],"funding":["Shahid Beheshti University of Medical Sciences","NIDDK NIH HHS"],"pagination":["e001033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7206914"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["<h4>Objective</h4>We assessed the therapeutic effects of photobiomodulation (PBM) and adipose-derived stem cell (ADS) treatments individually and together on the maturation step of repairing of a delayed healing wound model in rats with type 1 diabetes mellitus (DM1).<h4>Research design and methods</h4>We randomly assigned 24 rats with DM1 to four groups (n=6 per group). Group 1 was the control (placebo) group. In group 2, allograft human ADSs were transplanted. Group 3 was subjected to PBM (wavelength: 890 nm, peak power output: 80 W, pulse frequency: 80 Hz, pulsed duration: 180 ns, duration of exposure for each point: 200 s, power density: 0.001 W/cm<sup>2</sup>, energy density: 0.2 J/cm<sup>2</sup>) immediately after surgery, which continued for 6 days per week for 16 days. Group 4 rece"],"journal":["BMJ open diabetes research & care"],"pubmed_title":["Combined therapy of photobiomodulation and adipose-derived stem cells synergistically improve healing in an ischemic, infected and delayed healing wound model in rats with type 1 diabetes mellitus."],"pmcid":["PMC7206914"],"funding_grant_id":["R43 DK105692","R44 DK105692","14601"],"pubmed_authors":["Zare F","Bayat M","Ghoreishi SK","Amini A","Hashemi SM","Deravi N","Rahmanian M","Ebrahimpour-Malekshah R","Chien S","Mostafavinia A","Shafikhani S","Ahmadi H","Davoody S","Habibi M","Bayat S"],"additional_accession":[]},"is_claimable":false,"name":"Combined therapy of photobiomodulation and adipose-derived stem cells synergistically improve healing in an ischemic, infected and delayed healing wound model in rats with type 1 diabetes mellitus.","description":"<h4>Objective</h4>We assessed the therapeutic effects of photobiomodulation (PBM) and adipose-derived stem cell (ADS) treatments individually and together on the maturation step of repairing of a delayed healing wound model in rats with type 1 diabetes mellitus (DM1).<h4>Research design and methods</h4>We randomly assigned 24 rats with DM1 to four groups (n=6 per group). Group 1 was the control (placebo) group. In group 2, allograft human ADSs were transplanted. Group 3 was subjected to PBM (wavelength: 890 nm, peak power output: 80 W, pulse frequency: 80 Hz, pulsed duration: 180 ns, duration of exposure for each point: 200 s, power density: 0.001 W/cm<sup>2</sup>, energy density: 0.2 J/cm<sup>2</sup>) immediately after surgery, which continued for 6 days per week for 16 days. Group 4 rece","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2026-07-16T03:21:48.9Z","creation":"2026-07-09T10:32:12.077Z"},"accession":"S-EPMC7206914","cross_references":{"pubmed":["32098898"],"doi":["10.1136/bmjdrc-2019-001033"]}}