biostudies-literatureUnknown10(1)Yada YOur aim was to evaluate the association between ritodrine and magnesium sulfate (MgSO₄) and the occurrence of neonatal hyperkalemia or hypoglycemia among late preterm infants in a retrospective cohort study. We used a nationwide obstetrical database from 2014. A total of 4,622 live preterm infants born at 32-36 gestational weeks participated. Fourteen risk factors based on both clinical relevance and univariate analysis were adjusted in multivariable logistic regression analyses. Neonatal hyperkalemia and hypoglycemia occurred in 7.6% (284/3,732) and 32.4% (1,458/4,501), respectively. Occurrence of hyperkalemia was associated with concomitant usage of ritodrine and MgSO₄ compared with no usage (adjusted odds ratio [aOR] 1.53, 95% confidence interval [CI] 1.09-2.15). OScientific reports7804https://www.ebi.ac.uk/biostudies/studies/S-EPMC7210882biostudies-literatureSynergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study.PMC7210882Saito STabata NYasuo TKurabayashi TOtsuka HMiyakoshi KKawamura TAsada HKameda TTakayanagi TMatsuda YMorikawa SAkaba KMorikawa KNomiyama MOtsuki KSugahara KFukuyama AImai SDaigo MTakahata YYonemoto NYamada TNagara SYamanaka SNagayama YKanda HYamada MFujioka KYoshimura SOhki SOkabe MOkudate MYokomichi NToyofuku AFurukawa YTerada SShiga TMochizuki NKamei YKawaguchi HOgawa MYokoyama THirooka TShima WMiura RAdachi HMatsubara YNaito THokuto IOki NKai KHara SIshibashi NSekiguchi KTanaka RSasaki YTanaka TMiura AMiwa TYoshida MOhnuma EMure TSato AHigashino MOkuno RYamashita ASasahara JInagaki MOhta MHonda SSoeno YKondo STsuda HSahashi TMatsuo TNakanishi KOkuyama KOkamoto SSato HFukuda HKanagawa THirose MTakagi TNegishi HKikuchi NKosugiyama KGoto MHirose AKotera KSassa HArakaki HMurayama AKobayashi AOishi TKabashima STorii HYoshii KYasuda MFujikawa EFujiu TOhkuchi AMaruwaka KMiyashita YOkuda MNakashima MKunikata TKano MObara TBanzai MYano EOida KNakashima KKanto AYamamoto SKoshida SFukui OOta HSakai RFuruichi YYamamoto RUshida TFukaya SEto SOhmaru-Nakanishi TKodama YIkeda MIitsuka YYamamoto YNakamura YKojima YKurioka HArase THirose SSuzuki RHiraki HSuzuki TKagawa HTaguchi NAraki RHayashi SKuriyama NMitsuzuka KMizuno YMizushima MSurvey Group Studying the Effects of Tocolytic Agents on Neonatal Adverse Events in Japan Society of Perinatal and Neonatal MedicineKitazawa MKusuda SYoneda SImanishi YSomeya MKurasaki AIwasaki EHyodo HKato NUozumi AHida MShiro RTakahashi MOkahashi AHasegawa KNagata NWatanabe TOkada JKashinoura KGoishi KHiguchi KKasai MTsutsumi CKoroki MFujiwara KOshiro MYamauchi AFujisaka MMizunoe TOno HNobuzane TKataoka NTsukimori KMaruyama KTakeda AOhata TKasuga YIshimoto HYada YTakatera AMizutani TMiyoshi JNishida YfalseSynergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study.Our aim was to evaluate the association between ritodrine and magnesium sulfate (MgSO₄) and the occurrence of neonatal hyperkalemia or hypoglycemia among late preterm infants in a retrospective cohort study. We used a nationwide obstetrical database from 2014. A total of 4,622 live preterm infants born at 32-36 gestational weeks participated. Fourteen risk factors based on both clinical relevance and univariate analysis were adjusted in multivariable logistic regression analyses. Neonatal hyperkalemia and hypoglycemia occurred in 7.6% (284/3,732) and 32.4% (1,458/4,501), respectively. Occurrence of hyperkalemia was associated with concomitant usage of ritodrine and MgSO₄ compared with no usage (adjusted odds ratio [aOR] 1.53, 95% confidence interval [CI] 1.09-2.15). O2020-01-01T00:00:00Z2020 May2026-05-07T15:56:15.452Z2020-05-22T20:18:41ZS-EPMC72108823238535410.1038/s41598-020-64687-w