biostudies-literatureUnknown9(5)Zhang S<h4>Objectives</h4>Host immune responses are indispensable to combat the disease. We report the dynamics of peripheral immune cells, cytokines, and human leucocyte antigen-G (HLA-G) and its receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence.<h4>Methods</h4>Clinical data of the patient were collected from medical records. The expressions of HLA-G and receptors ILT2, ILT4 and KIR2DL4 in peripheral immune cells were measured with flow cytometry.<h4>Results</h4>From critical COVID-19 to the convalescent stage, early lymphopenia was improved (median: 0.6 × 10⁹ L^-1 vs. 0.9 × 10⁹ L^-1, <i>P</i> = 0.009), and an obvious fluctuation in WBC and neutrophil counts was observed. Initially, low levels of CD4<sup>+</supClinical & translational immunologye1128https://www.ebi.ac.uk/biostudies/studies/S-EPMC7211507biostudies-literatureDynamics of peripheral immune cells and their HLA-G and receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence.PMC7211507Lin AYan WHZhang JGGan JZhou YPZhang SChen BGZheng DLin RHYang WYfalseDynamics of peripheral immune cells and their HLA-G and receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence.<h4>Objectives</h4>Host immune responses are indispensable to combat the disease. We report the dynamics of peripheral immune cells, cytokines, and human leucocyte antigen-G (HLA-G) and its receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence.<h4>Methods</h4>Clinical data of the patient were collected from medical records. The expressions of HLA-G and receptors ILT2, ILT4 and KIR2DL4 in peripheral immune cells were measured with flow cytometry.<h4>Results</h4>From critical COVID-19 to the convalescent stage, early lymphopenia was improved (median: 0.6 × 10⁹ L^-1 vs. 0.9 × 10⁹ L^-1, <i>P</i> = 0.009), and an obvious fluctuation in WBC and neutrophil counts was observed. Initially, low levels of CD4<sup>+</sup2020-01-01T00:00:00Z2020 May2025-04-19T01:46:39.283Z2020-05-22T20:07:43ZS-EPMC72115073239921310.1002/cti2.1128